Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4342229..4342824 Replicon chromosome
Accession NZ_CP031898
Organism Escherichia coli O113:H21 strain FWSEC0010

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag C8201_RS21445 Protein ID WP_000239579.1
Coordinates 4342229..4342579 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag C8201_RS21450 Protein ID WP_001223208.1
Coordinates 4342573..4342824 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C8201_RS21425 4337505..4338527 - 1023 WP_001339490.1 ABC transporter permease -
C8201_RS21430 4338541..4340043 - 1503 WP_000205793.1 sugar ABC transporter ATP-binding protein -
C8201_RS21435 4340353..4341309 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
C8201_RS21440 4341619..4342149 + 531 WP_000055072.1 inorganic diphosphatase -
C8201_RS21445 4342229..4342579 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
C8201_RS21450 4342573..4342824 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
C8201_RS21455 4343037..4343378 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
C8201_RS21460 4343381..4347160 - 3780 WP_000060901.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T110546 WP_000239579.1 NZ_CP031898:c4342579-4342229 [Escherichia coli O113:H21]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T110546 NZ_CP031898:c4342579-4342229 [Escherichia coli O113:H21]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT110546 WP_001223208.1 NZ_CP031898:c4342824-4342573 [Escherichia coli O113:H21]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT110546 NZ_CP031898:c4342824-4342573 [Escherichia coli O113:H21]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References