Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | paaR-paaA-parE/- |
| Location | 2935297..2935768 | Replicon | chromosome |
| Accession | NZ_CP031898 | ||
| Organism | Escherichia coli O113:H21 strain FWSEC0010 | ||
Toxin (Protein)
| Gene name | parE_1 | Uniprot ID | A0A0D7C2L1 |
| Locus tag | C8201_RS14775 | Protein ID | WP_001303511.1 |
| Coordinates | 2935490..2935768 (+) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | paaA | Uniprot ID | Q8XAD5 |
| Locus tag | C8201_RS14770 | Protein ID | WP_001302048.1 |
| Coordinates | 2935297..2935488 (+) | Length | 64 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C8201_RS25570 | 2930665..2930841 | - | 177 | WP_000753060.1 | hypothetical protein | - |
| C8201_RS14725 | 2930834..2931016 | - | 183 | WP_001224672.1 | hypothetical protein | - |
| C8201_RS14730 | 2931164..2931469 | - | 306 | WP_072094475.1 | DUF4406 domain-containing protein | - |
| C8201_RS14735 | 2931466..2931747 | - | 282 | WP_072094476.1 | DNA-binding protein | - |
| C8201_RS14740 | 2931780..2932496 | - | 717 | WP_028985606.1 | DUF1627 domain-containing protein | - |
| C8201_RS14745 | 2932530..2932991 | - | 462 | WP_000139447.1 | replication protein | - |
| C8201_RS14750 | 2932984..2934015 | - | 1032 | WP_050868113.1 | phage replisome organizer | - |
| C8201_RS14755 | 2934084..2934509 | - | 426 | WP_000693925.1 | Rha family transcriptional regulator | - |
| C8201_RS14760 | 2934506..2934808 | - | 303 | WP_032279888.1 | transcriptional regulator | - |
| C8201_RS14765 | 2934905..2935276 | + | 372 | WP_001169685.1 | hypothetical protein | - |
| C8201_RS14770 | 2935297..2935488 | + | 192 | WP_001302048.1 | hypothetical protein | Antitoxin |
| C8201_RS14775 | 2935490..2935768 | + | 279 | WP_001303511.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| C8201_RS14780 | 2936059..2936211 | + | 153 | WP_000367379.1 | DUF1391 family protein | - |
| C8201_RS14785 | 2936325..2936840 | - | 516 | WP_000559920.1 | hypothetical protein | - |
| C8201_RS14795 | 2937369..2937557 | + | 189 | WP_000450222.1 | cell division inhibitor | - |
| C8201_RS14800 | 2937554..2937742 | + | 189 | WP_000092784.1 | DUF1482 family protein | - |
| C8201_RS14805 | 2937835..2940279 | + | 2445 | WP_000102189.1 | exonuclease | - |
| C8201_RS14810 | 2940341..2940610 | + | 270 | WP_000003742.1 | excisionase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | stx2B / stx2A | 2915147..2945005 | 29858 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 10661.25 Da Isoelectric Point: 5.5647
>T110542 WP_001303511.1 NZ_CP031898:2935490-2935768 [Escherichia coli O113:H21]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP
Download Length: 279 bp
>T110542 NZ_CP031898:2935490-2935768 [Escherichia coli O113:H21]
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCAGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTGGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
ATGTTACCCGTGTTATGGCTTGAAAGCGCAGATACCGACCTAGATGATATAACTAGTTATATTGCTCGTTTCGACATAGA
TGCGGCAGAACGCTTATGGCAGCGATTAAGGGGTTGTGTGCTGCCGTTATCCGAACATCCGTATTTATACCCACCAAGCG
ACAGAGTACCTGGCTTGCGTGAGATTGTGGCCCACCCTAACTATATAATTCTATACCGCGTAACAACATCAAGCGTTGAA
GTAGTAAACGTGATCCACGCAAGACGCCAGTTTCCCTAA
Antitoxin
Download Length: 64 a.a. Molecular weight: 7463.47 Da Isoelectric Point: 8.6828
>AT110542 WP_001302048.1 NZ_CP031898:2935297-2935488 [Escherichia coli O113:H21]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ
Download Length: 192 bp
>AT110542 NZ_CP031898:2935297-2935488 [Escherichia coli O113:H21]
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAGTTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
ATGAATAGAGCCCTTTCACCAATGGTTTCTGAGTTTGAAACCATTGAACAAGAAAACAGTTACAACGAATGGCTGCGTGC
GAAAGTAGCAACGAGCCTTGCAGATCCGCGCCCAGCAATTCCCCATGACGAAGTTGAGCGCAGAATGGCAGAACGCTTTG
CTAAAATGCGCAAGGAACGGAGCAAGCAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|