Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 878799..879276 Replicon chromosome
Accession NZ_CP031890
Organism Staphylococcus aureus strain CFSAN082781

Toxin (Protein)


Gene name TsaT Uniprot ID Q2G005
Locus tag D1E87_RS04350 Protein ID WP_000052078.1
Coordinates 878799..878987 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag D1E87_RS04355 Protein ID WP_001059690.1
Coordinates 879016..879276 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1E87_RS04320 874840..875310 + 471 WP_000824472.1 hypothetical protein -
D1E87_RS04325 875651..876337 + 687 WP_001548082.1 thermonuclease family protein -
D1E87_RS04330 876694..876894 + 201 WP_001059082.1 cold-shock protein -
D1E87_RS04335 877390..877608 - 219 WP_000005886.1 hypothetical protein -
D1E87_RS04340 877670..877954 - 285 WP_001004395.1 hypothetical protein -
D1E87_RS04345 878042..878611 - 570 WP_001106654.1 hypothetical protein -
D1E87_RS04350 878799..878987 - 189 WP_000052078.1 hypothetical protein Toxin
D1E87_RS04355 879016..879276 - 261 WP_001059690.1 hypothetical protein Antitoxin
D1E87_RS04360 879617..879820 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
D1E87_RS04365 879817..880053 - 237 WP_000368687.1 hypothetical protein -
D1E87_RS04370 880278..880859 + 582 WP_001140686.1 phosphoglycerate mutase family protein -
D1E87_RS04375 880932..881549 - 618 WP_000255561.1 LysE/ArgO family amino acid transporter -
D1E87_RS04380 881704..882198 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
D1E87_RS04385 882597..883019 - 423 WP_000974460.1 organic hydroperoxide resistance protein -
D1E87_RS04390 883167..883883 + 717 WP_000150017.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - selk / selq 873483..904564 31081


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7172.84 Da        Isoelectric Point: 9.9971

>T110510 WP_000052078.1 NZ_CP031890:c878987-878799 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTSKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T110510 NZ_CP031890:c878987-878799 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTAGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT110510 WP_001059690.1 NZ_CP031890:c879276-879016 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT110510 NZ_CP031890:c879276-879016 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D6HZ40

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References