Detailed information of TA system TA110490

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2078112..2078641
• Replicon: chromosome
• Accession: NZ_CP031886
• Organism: Staphylococcus aureus strain CFSAN082783

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: D1E88_RS10515
• Protein ID: WP_000621175.1
• Coordinates: 2078112..2078474 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: D1E88_RS10520
• Protein ID: WP_000948331.1
• Coordinates: 2078471..2078641 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1E88_RS10495	2075090..2075860	-	771	WP_001041107.1	RNA polymerase sigma factor SigB	-
D1E88_RS10500	2075835..2076314	-	480	WP_001190825.1	anti-sigma B factor RsbW	-
D1E88_RS10505	2076316..2076642	-	327	WP_001052491.1	anti-sigma factor antagonist	-
D1E88_RS10510	2076761..2077762	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
D1E88_RS10515	2078112..2078474	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
D1E88_RS10520	2078471..2078641	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
D1E88_RS10525	2078726..2079874	-	1149	WP_001281140.1	alanine racemase	-
D1E88_RS10530	2079940..2080299	-	360	WP_000581199.1	holo-ACP synthase	-
D1E88_RS10535	2080303..2080794	-	492	WP_001205907.1	PH domain-containing protein	-
D1E88_RS10540	2080781..2082364	-	1584	WP_001294637.1	PH domain-containing protein	-
D1E88_RS10545	2082357..2082836	-	480	WP_001287077.1	hypothetical protein	-
D1E88_RS10550	2083044..2083604	-	561	WP_001092406.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T110490 WP_000621175.1 NZ_CP031886:c2078474-2078112 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T110490 NZ_CP031886:c2078474-2078112 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAGCAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT110490 WP_000948331.1 NZ_CP031886:c2078641-2078471 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT110490 NZ_CP031886:c2078641-2078471 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1