Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 1909175..1909963 Replicon chromosome
Accession NZ_CP031886
Organism Staphylococcus aureus strain CFSAN082783

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag D1E88_RS09525 Protein ID WP_000525004.1
Coordinates 1909502..1909963 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag D1E88_RS09520 Protein ID WP_000333630.1
Coordinates 1909175..1909489 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1E88_RS09465 1904583..1905206 - 624 WP_000139720.1 DUF1071 domain-containing protein -
D1E88_RS09470 1905199..1905420 - 222 WP_001077280.1 DUF2483 family protein -
D1E88_RS09475 1905430..1905690 - 261 WP_000291090.1 DUF1108 family protein -
D1E88_RS09480 1905787..1905948 - 162 WP_000066011.1 DUF1270 domain-containing protein -
D1E88_RS09485 1905941..1906162 - 222 WP_000594789.1 hypothetical protein -
D1E88_RS09490 1906233..1906463 + 231 WP_000395455.1 hypothetical protein -
D1E88_RS09495 1906639..1907379 - 741 WP_001148589.1 phage antirepressor KilAC domain-containing protein -
D1E88_RS09500 1907381..1907566 - 186 WP_000933365.1 helix-turn-helix transcriptional regulator -
D1E88_RS09505 1908012..1908494 + 483 WP_000394410.1 hypothetical protein -
D1E88_RS09510 1908595..1908774 - 180 WP_000438352.1 hypothetical protein -
D1E88_RS09515 1908793..1909023 - 231 WP_103263741.1 helix-turn-helix domain-containing protein -
D1E88_RS09520 1909175..1909489 + 315 WP_000333630.1 helix-turn-helix domain-containing protein Antitoxin
D1E88_RS09525 1909502..1909963 + 462 WP_000525004.1 hypothetical protein Toxin
D1E88_RS09530 1910147..1911079 + 933 WP_000392183.1 hypothetical protein -
D1E88_RS09535 1911059..1911238 - 180 WP_000337827.1 hypothetical protein -
D1E88_RS09540 1911351..1912397 + 1047 WP_001145722.1 site-specific integrase -
D1E88_RS09545 1912442..1913587 + 1146 WP_001622132.1 radical SAM/CxCxxxxC motif protein YfkAB -
D1E88_RS09550 1913850..1914380 - 531 WP_000184383.1 acyl-CoA thioesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1869054..1912397 43343


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T110487 WP_000525004.1 NZ_CP031886:1909502-1909963 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

>T110487 NZ_CP031886:1909502-1909963 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTGCTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTGATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGGATTCTCTTTGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCACGT
AGACACGGCTTTATCTCAGCTGTTCCATTACGCGAAATTGTAGAAGCTTATAATTATGGCGTACGTAACTTGTATGAATT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCGATCACATTTGAGCCGTTGAGAGTTTTTAAATATAAGGAAATATAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT110487 WP_000333630.1 NZ_CP031886:1909175-1909489 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT110487 NZ_CP031886:1909175-1909489 [Staphylococcus aureus]
ATGTGCTTTTCAAAAAGAATGAAACAATCAAGAGAAAAACAAGGTATGACTTTGGCCGAACTAGGAAGAAAAATTGGTAA
AACTGAAGCTACTGTACAACGTTATGAAAGCGGAAATATCAAAAATCTAAAAAACGATACTATAGAAAGTATAGCTACTG
CATTAAATGTTAATCCTGCGTATTTAATGGGGTGGGTTGAAGAAAACGATGATGAAGTACAACATCGTGCAGCTCATCTT
GAAGGAGAATTGACAGATGACGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAAACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References