Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 820897..821374 Replicon chromosome
Accession NZ_CP031886
Organism Staphylococcus aureus strain CFSAN082783

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag D1E88_RS03945 Protein ID WP_000052076.1
Coordinates 820897..821085 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag D1E88_RS03950 Protein ID WP_001059690.1
Coordinates 821114..821374 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1E88_RS03915 816887..817408 + 522 WP_000824479.1 hypothetical protein -
D1E88_RS03920 817749..818435 + 687 WP_001622483.1 thermonuclease family protein -
D1E88_RS03925 818792..818992 + 201 WP_001059082.1 cold-shock protein -
D1E88_RS03930 819489..819707 - 219 WP_000005875.1 hypothetical protein -
D1E88_RS03935 819780..820052 - 273 WP_001004400.1 hypothetical protein -
D1E88_RS03940 820140..820709 - 570 WP_001106662.1 hypothetical protein -
D1E88_RS03945 820897..821085 - 189 WP_000052076.1 hypothetical protein Toxin
D1E88_RS03950 821114..821374 - 261 WP_001059690.1 hypothetical protein Antitoxin
D1E88_RS03955 821715..821918 + 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
D1E88_RS03960 821915..822151 - 237 WP_000368687.1 hypothetical protein -
D1E88_RS03965 822375..822956 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
D1E88_RS03970 823029..823646 - 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
D1E88_RS03975 823802..824296 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
D1E88_RS03980 824695..825117 - 423 WP_000974451.1 organic hydroperoxide resistance protein -
D1E88_RS03985 825265..825981 + 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-50)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T110485 WP_000052076.1 NZ_CP031886:c821085-820897 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T110485 NZ_CP031886:c821085-820897 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT110485 WP_001059690.1 NZ_CP031886:c821374-821114 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT110485 NZ_CP031886:c821374-821114 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References