Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4664353..4664869 Replicon chromosome
Accession NZ_CP031885
Organism Klebsiella pneumoniae strain WCHKP095845

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag BT110_RS24785 Protein ID WP_004178374.1
Coordinates 4664353..4664637 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag BT110_RS24790 Protein ID WP_002886901.1
Coordinates 4664627..4664869 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BT110_RS24765 4659748..4660056 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
BT110_RS28655 4660141..4660314 + 174 WP_032412860.1 hypothetical protein -
BT110_RS24770 4660317..4661060 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
BT110_RS24775 4661417..4663555 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
BT110_RS24780 4663885..4664349 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
BT110_RS24785 4664353..4664637 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BT110_RS24790 4664627..4664869 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BT110_RS24795 4664947..4666857 - 1911 WP_004152270.1 BglG family transcription antiterminator -
BT110_RS24800 4666880..4668034 - 1155 WP_002886900.1 lactonase family protein -
BT110_RS24805 4668101..4668841 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T110482 WP_004178374.1 NZ_CP031885:c4664637-4664353 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T110482 NZ_CP031885:c4664637-4664353 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCTGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT110482 WP_002886901.1 NZ_CP031885:c4664869-4664627 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT110482 NZ_CP031885:c4664869-4664627 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References