Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3941126..3941745 Replicon chromosome
Accession NZ_CP031885
Organism Klebsiella pneumoniae strain WCHKP095845

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag BT110_RS21285 Protein ID WP_002892050.1
Coordinates 3941527..3941745 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag BT110_RS21280 Protein ID WP_002892066.1
Coordinates 3941126..3941500 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BT110_RS21270 3936278..3937471 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
BT110_RS21275 3937494..3940640 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
BT110_RS21280 3941126..3941500 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
BT110_RS21285 3941527..3941745 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
BT110_RS21290 3941908..3942474 + 567 WP_002892030.1 maltose O-acetyltransferase -
BT110_RS28515 3942446..3942586 - 141 WP_004147370.1 hypothetical protein -
BT110_RS21295 3942607..3943077 + 471 WP_002892026.1 YlaC family protein -
BT110_RS21300 3943052..3944503 - 1452 WP_064151794.1 PLP-dependent aminotransferase family protein -
BT110_RS21305 3944604..3945302 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
BT110_RS21310 3945299..3945439 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
BT110_RS21315 3945439..3945702 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T110480 WP_002892050.1 NZ_CP031885:3941527-3941745 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T110480 NZ_CP031885:3941527-3941745 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT110480 WP_002892066.1 NZ_CP031885:3941126-3941500 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT110480 NZ_CP031885:3941126-3941500 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References