Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 831492..832149 Replicon chromosome
Accession NZ_CP031885
Organism Klebsiella pneumoniae strain WCHKP095845

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag BT110_RS05680 Protein ID WP_002916310.1
Coordinates 831739..832149 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag BT110_RS05675 Protein ID WP_002916312.1
Coordinates 831492..831758 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BT110_RS05650 826648..828081 - 1434 WP_064152027.1 6-phospho-beta-glucosidase -
BT110_RS05655 828200..828928 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
BT110_RS05660 828978..829289 + 312 WP_064152028.1 N(4)-acetylcytidine aminohydrolase -
BT110_RS05665 829453..830112 + 660 WP_002916317.1 hemolysin III family protein -
BT110_RS05670 830263..831246 - 984 WP_064152029.1 tRNA-modifying protein YgfZ -
BT110_RS05675 831492..831758 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
BT110_RS05680 831739..832149 + 411 WP_002916310.1 protein YgfX Toxin
BT110_RS05685 832156..832677 - 522 WP_004144730.1 flavodoxin FldB -
BT110_RS05690 832778..833674 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
BT110_RS05695 833697..834410 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
BT110_RS05700 834416..836149 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T110470 WP_002916310.1 NZ_CP031885:831739-832149 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T110470 NZ_CP031885:831739-832149 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT110470 WP_002916312.1 NZ_CP031885:831492-831758 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT110470 NZ_CP031885:831492-831758 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References