Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1744956..1745687 | Replicon | chromosome |
| Accession | NZ_CP031875 | ||
| Organism | Actinobacillus pleuropneumoniae serovar | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A448U107 |
| Locus tag | D1095_RS08030 | Protein ID | WP_005602211.1 |
| Coordinates | 1744956..1745423 (-) | Length | 156 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | B0BRD3 |
| Locus tag | D1095_RS08035 | Protein ID | WP_005619269.1 |
| Coordinates | 1745427..1745687 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D1095_RS08005 (D1095_08100) | 1740315..1740686 | - | 372 | WP_005598830.1 | CrcB family protein | - |
| D1095_RS08010 (D1095_08105) | 1740689..1741753 | - | 1065 | WP_005602204.1 | MFS transporter | - |
| D1095_RS08015 (D1095_08110) | 1741848..1742957 | + | 1110 | WP_005602206.1 | anhydro-N-acetylmuramic acid kinase | - |
| D1095_RS08020 (D1095_08115) | 1743011..1743925 | + | 915 | WP_005602207.1 | N-acetylmuramic acid 6-phosphate etherase | - |
| D1095_RS08025 (D1095_08120) | 1743992..1744873 | - | 882 | WP_005602209.1 | 50S ribosomal protein L11 methyltransferase | - |
| D1095_RS08030 (D1095_08125) | 1744956..1745423 | - | 468 | WP_005602211.1 | GNAT family N-acetyltransferase | Toxin |
| D1095_RS08035 (D1095_08130) | 1745427..1745687 | - | 261 | WP_005619269.1 | DUF1778 domain-containing protein | Antitoxin |
| D1095_RS08040 (D1095_08135) | 1745808..1747268 | - | 1461 | WP_005598844.1 | metalloprotease TldD | - |
| D1095_RS08045 (D1095_08140) | 1747398..1748657 | + | 1260 | WP_005615928.1 | tRNA lysidine(34) synthetase TilS | - |
| D1095_RS08050 (D1095_08145) | 1748684..1748974 | - | 291 | WP_005602215.1 | DUF5389 family protein | - |
| D1095_RS08055 (D1095_08150) | 1748976..1749869 | - | 894 | WP_005598850.1 | site-specific tyrosine recombinase XerD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 156 a.a. Molecular weight: 17192.19 Da Isoelectric Point: 8.9312
>T110464 WP_005602211.1 NZ_CP031875:c1745423-1744956 [Actinobacillus pleuropneumoniae serovar 2 str. S1536]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL
Download Length: 468 bp
>T110464 NZ_CP031875:c1745423-1744956 [Actinobacillus pleuropneumoniae serovar 2 str. S1536]
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGAAAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGTGCCTTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGTTCGGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAACCCGCAAGCAAAAC
AATTTTATTTAAAGTATGGTTTTTCATGTTCACCCATTGATGAGATGGTATTAATGTTAAAACTCTAA
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGAAAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGTGCCTTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGTTCGGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAACCCGCAAGCAAAAC
AATTTTATTTAAAGTATGGTTTTTCATGTTCACCCATTGATGAGATGGTATTAATGTTAAAACTCTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9796.14 Da Isoelectric Point: 4.4883
>AT110464 WP_005619269.1 NZ_CP031875:c1745687-1745427 [Actinobacillus pleuropneumoniae serovar 2 str. S1536]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE
Download Length: 261 bp
>AT110464 NZ_CP031875:c1745687-1745427 [Actinobacillus pleuropneumoniae serovar 2 str. S1536]
ATGAGAACTGCGCCAATTAATTTACGAGCGATGCCTGATCAGCGTGATTTAATTGATTATGCGGCAAGCATTTTAGGTAA
AACACGTTCTGACTTTATGTTAGAAACCGCCTGCCAAGCTGCCCAAAATGTGATTTTAGATCGTACCGTTTTCCAATTAA
ATGAGCAGGCTTTCGAGCAATTTAACCGATTGCTAGAACAGCCAACAGCAGATAATCCGGGGTTAGATAAACTGTTAAAT
ACCAAAGCGGTGTGGGAGTAG
ATGAGAACTGCGCCAATTAATTTACGAGCGATGCCTGATCAGCGTGATTTAATTGATTATGCGGCAAGCATTTTAGGTAA
AACACGTTCTGACTTTATGTTAGAAACCGCCTGCCAAGCTGCCCAAAATGTGATTTTAGATCGTACCGTTTTCCAATTAA
ATGAGCAGGCTTTCGAGCAATTTAACCGATTGCTAGAACAGCCAACAGCAGATAATCCGGGGTTAGATAAACTGTTAAAT
ACCAAAGCGGTGTGGGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A448U107 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A3N2I7 |