Detailed information of TA system TA110463

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1538295..1538940
• Replicon: chromosome
• Accession: NZ_CP031875
• Organism: Actinobacillus pleuropneumoniae serovar

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: B0BQU7
• Locus tag: D1095_RS07005
• Protein ID: WP_005619674.1
• Coordinates: 1538569..1538940 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: D1095_RS07000
• Protein ID: WP_005598477.1
• Coordinates: 1538295..1538588 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1095_RS06970 (D1095_07060)	1533627..1534310	-	684	WP_005601946.1	arginine ABC transporter permease ArtM	-
D1095_RS06975 (D1095_07065)	1534310..1534981	-	672	WP_005601949.1	arginine ABC transporter permease ArtQ	-
D1095_RS06980 (D1095_07070)	1534987..1535706	-	720	WP_005619670.1	transporter substrate-binding domain-containing protein	-
D1095_RS06985 (D1095_07075)	1535726..1536460	-	735	WP_005598473.1	arginine ABC transporter ATP-binding protein ArtP	-
D1095_RS06990 (D1095_07080)	1536685..1537182	-	498	WP_005601953.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
D1095_RS06995 (D1095_07085)	1537255..1538217	+	963	WP_005619672.1	calcium/sodium antiporter	-
D1095_RS07000 (D1095_07090)	1538295..1538588	-	294	WP_005598477.1	helix-turn-helix domain-containing protein	Antitoxin
D1095_RS07005 (D1095_07095)	1538569..1538940	-	372	WP_005619674.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1095_RS07010 (D1095_07100)	1539134..1540885	+	1752	WP_005601957.1	protein-disulfide reductase DsbD	-
D1095_RS07015 (D1095_07105)	1540943..1541512	+	570	WP_005601959.1	elongation factor P hydroxylase	-
D1095_RS07020 (D1095_07110)	1541556..1542410	-	855	WP_005598486.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (32-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 15066.57 Da
• Isoelectric Point: 10.4054

>T110463 WP_005619674.1 NZ_CP031875:c1538940-1538569 [Actinobacillus pleuropneumoniae serovar 2 str. S1536]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Nucleotide

• Length: 372 bp

>T110463 NZ_CP031875:c1538940-1538569 [Actinobacillus pleuropneumoniae serovar 2 str. S1536]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTACTAAAAGAACG
GCAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGTCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10935.81 Da
• Isoelectric Point: 10.3120

>AT110463 WP_005598477.1 NZ_CP031875:c1538588-1538295 [Actinobacillus pleuropneumoniae serovar 2 str. S1536]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Nucleotide

• Length: 294 bp

>AT110463 NZ_CP031875:c1538588-1538295 [Actinobacillus pleuropneumoniae serovar 2 str. S1536]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTCGGAAATAGCGGAAACTCAGTTTCG
CATACGACTTATTTTAGAAATCATTGAAACCCGTCAGCAGCTCGGTATTTCTCAACGAAAATTGGAGAAATTAAGCGGCG
TAAAACAATCTATGATTGCTCGGGTAGAAAAAGGCTCGGTTAATCCGTCGTTGGCGACGGTATTAAAGTTGCTTGTGCCG
TTGGGGAAAACTTTACAAATCGTACCGTTAGATAAAAACAAAACGGTACGTTAA

Structures

Toxin

• AlphaFold DB: A3N206