Detailed information of TA system TA110453

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1556367..1557012
• Replicon: chromosome
• Accession: NZ_CP031873
• Organism: Actinobacillus pleuropneumoniae serovar 4 str. M62

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: B0BQU7
• Locus tag: D1097_RS07210
• Protein ID: WP_005619674.1
• Coordinates: 1556641..1557012 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: D1097_RS07205
• Protein ID: WP_005598477.1
• Coordinates: 1556367..1556660 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1097_RS07175 (D1097_07200)	1551699..1552382	-	684	WP_005605188.1	arginine ABC transporter permease ArtM	-
D1097_RS07180 (D1097_07205)	1552382..1553053	-	672	WP_005605189.1	arginine ABC transporter permease ArtQ	-
D1097_RS07185 (D1097_07210)	1553059..1553778	-	720	WP_043990955.1	transporter substrate-binding domain-containing protein	-
D1097_RS07190 (D1097_07215)	1553798..1554532	-	735	WP_005605201.1	arginine ABC transporter ATP-binding protein ArtP	-
D1097_RS07195 (D1097_07220)	1554757..1555254	-	498	WP_005601953.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
D1097_RS07200 (D1097_07225)	1555327..1556289	+	963	WP_005619672.1	calcium/sodium antiporter	-
D1097_RS07205 (D1097_07230)	1556367..1556660	-	294	WP_005598477.1	helix-turn-helix domain-containing protein	Antitoxin
D1097_RS07210 (D1097_07235)	1556641..1557012	-	372	WP_005619674.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1097_RS07215 (D1097_07240)	1557206..1558957	+	1752	WP_005601957.1	protein-disulfide reductase DsbD	-
D1097_RS07220 (D1097_07245)	1559015..1559584	+	570	WP_005605204.1	elongation factor P hydroxylase	-
D1097_RS07225 (D1097_07250)	1559628..1560482	-	855	WP_005605207.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (32-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 15066.57 Da
• Isoelectric Point: 10.4054

>T110453 WP_005619674.1 NZ_CP031873:c1557012-1556641 [Actinobacillus pleuropneumoniae serovar 4 str. M62]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Nucleotide

• Length: 372 bp

>T110453 NZ_CP031873:c1557012-1556641 [Actinobacillus pleuropneumoniae serovar 4 str. M62]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTACTAAAAGAACG
GCAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGCCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10935.81 Da
• Isoelectric Point: 10.3120

>AT110453 WP_005598477.1 NZ_CP031873:c1556660-1556367 [Actinobacillus pleuropneumoniae serovar 4 str. M62]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Nucleotide

• Length: 294 bp

>AT110453 NZ_CP031873:c1556660-1556367 [Actinobacillus pleuropneumoniae serovar 4 str. M62]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTCGGAAATAGCGGAAACTCAGTTTCG
CATACGACTTATTTTAGAAATCATTGAAACCCGTCAGCAGCTCGGTATTTCTCAACGAAAATTGGAGAAATTAAGCGGCG
TAAAACAATCTATGATTGCTCGGGTAGAAAAAGGCTCGGTTAATCCGTCGTTGGCGACGGTATTAAAGTTGCTTGTGCCG
TTGGGGAAAACTTTACAAATCGTACCGTTAGATAAAAACAAAACGGTACGTTAA

Structures

Toxin

• AlphaFold DB: A3N206