Detailed information of TA system TA110451

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 834743..835393
• Replicon: chromosome
• Accession: NZ_CP031873
• Organism: Actinobacillus pleuropneumoniae serovar 4 str. M62

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1097_RS03860
• Protein ID: WP_005604115.1
• Coordinates: 835004..835393 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B0BNU4
• Locus tag: D1097_RS03855
• Protein ID: WP_005604117.1
• Coordinates: 834743..835003 (+)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1097_RS03835 (D1097_03825)	829763..830383	-	621	WP_005596976.1	hypothetical protein	-
D1097_RS03840 (D1097_03830)	830394..831587	-	1194	WP_005604123.1	iron uptake transporter deferrochelatase/peroxidase subunit	-
D1097_RS03845 (D1097_03835)	831599..832411	-	813	WP_005604121.1	iron uptake system protein EfeO	-
D1097_RS03850 (D1097_03845)	832588..834609	+	2022	WP_005604119.1	excinuclease ABC subunit UvrB	-
D1097_RS03855 (D1097_03850)	834743..835003	+	261	WP_005604117.1	hypothetical protein	Antitoxin
D1097_RS03860 (D1097_03855)	835004..835393	+	390	WP_005604115.1	type II toxin-antitoxin system VapC family toxin	Toxin
D1097_RS03865 (D1097_03860)	835529..836752	+	1224	WP_005604113.1	ATP-binding protein	-
D1097_RS03870 (D1097_03865)	836878..839190	+	2313	WP_005604111.1	SNF2-related protein	-
D1097_RS03875	839175..840152	+	978	WP_237592521.1	C-terminal helicase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-117)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14895.21 Da
• Isoelectric Point: 4.8482

>T110451 WP_005604115.1 NZ_CP031873:835004-835393 [Actinobacillus pleuropneumoniae serovar 4 str. M62]
MYMLDTNTVSYFFRQDPTVVKKLQQLNPELICISSVTAAELFYGVKKRNNQKLTAFLNTFLSAITVMDWDYQVAEVYGQL
RAEMEREGKIMGVQDQMIGAHALETECVLVSSDKAFQFIPNLVLENWWK

Nucleotide

• Length: 390 bp

>T110451 NZ_CP031873:835004-835393 [Actinobacillus pleuropneumoniae serovar 4 str. M62]
ATGTATATGCTAGATACTAATACGGTGAGTTATTTCTTTAGGCAAGATCCTACTGTGGTTAAGAAACTACAACAACTTAA
TCCGGAATTGATTTGTATTTCATCGGTCACGGCTGCAGAGTTGTTTTATGGCGTAAAAAAACGTAATAATCAGAAACTTA
CTGCATTTTTAAATACTTTTTTATCTGCGATTACGGTGATGGATTGGGATTATCAAGTGGCGGAAGTTTATGGTCAGCTG
CGAGCAGAGATGGAACGAGAAGGCAAAATCATGGGCGTTCAAGATCAAATGATTGGAGCTCATGCCCTAGAAACAGAATG
TGTTCTTGTTTCCAGCGATAAAGCCTTTCAATTTATCCCTAATCTCGTATTAGAAAATTGGTGGAAGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10289.63 Da
• Isoelectric Point: 5.1867

>AT110451 WP_005604117.1 NZ_CP031873:834743-835003 [Actinobacillus pleuropneumoniae serovar 4 str. M62]
MEKVARLFRNGRNQAVRLPVEFEFNAKQVYVFKEANGDITLSTRSRNQQNWQKVFELLPMLECDEQFLSEQERKQEMATR
DPFEGF

Nucleotide

• Length: 261 bp

>AT110451 NZ_CP031873:834743-835003 [Actinobacillus pleuropneumoniae serovar 4 str. M62]
ATGGAAAAGGTCGCACGTTTATTTAGAAACGGACGTAATCAAGCCGTACGATTACCGGTTGAATTTGAGTTTAATGCGAA
GCAAGTTTATGTGTTTAAAGAAGCAAACGGCGATATTACGCTTTCGACACGTTCTCGCAATCAGCAAAATTGGCAGAAAG
TCTTTGAGTTATTACCAATGCTTGAATGTGATGAACAGTTTTTATCGGAACAAGAACGCAAGCAAGAAATGGCAACTCGA
GATCCGTTCGAGGGCTTTTAA

Structures

Antitoxin

• AlphaFold DB: A3N030