Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1918344..1919075 Replicon chromosome
Accession NZ_CP031869
Organism Actinobacillus pleuropneumoniae strain WF83

Toxin (Protein)


Gene name tacT Uniprot ID A0A448U107
Locus tag D1100_RS09110 Protein ID WP_005602211.1
Coordinates 1918608..1919075 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID B0BRD3
Locus tag D1100_RS09105 Protein ID WP_005619269.1
Coordinates 1918344..1918604 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1100_RS09085 (D1100_09145) 1914162..1915055 + 894 WP_005618012.1 site-specific tyrosine recombinase XerD -
D1100_RS09090 (D1100_09150) 1915057..1915347 + 291 WP_005602215.1 DUF5389 family protein -
D1100_RS09095 (D1100_09155) 1915374..1916633 - 1260 WP_005618010.1 tRNA lysidine(34) synthetase TilS -
D1100_RS09100 (D1100_09160) 1916763..1918223 + 1461 WP_237601108.1 metalloprotease TldD -
D1100_RS09105 (D1100_09165) 1918344..1918604 + 261 WP_005619269.1 DUF1778 domain-containing protein Antitoxin
D1100_RS09110 (D1100_09170) 1918608..1919075 + 468 WP_005602211.1 GNAT family N-acetyltransferase Toxin
D1100_RS09115 (D1100_09175) 1919159..1920040 + 882 WP_012478550.1 50S ribosomal protein L11 methyltransferase -
D1100_RS09120 (D1100_09180) 1920107..1921021 - 915 WP_005618000.1 N-acetylmuramic acid 6-phosphate etherase -
D1100_RS09125 (D1100_09185) 1921075..1922184 - 1110 WP_005617998.1 anhydro-N-acetylmuramic acid kinase -
D1100_RS09130 (D1100_09190) 1922279..1923343 + 1065 WP_012478549.1 MFS transporter -
D1100_RS09135 (D1100_09195) 1923346..1923717 + 372 WP_005598830.1 CrcB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(22-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17192.19 Da        Isoelectric Point: 8.9312

>T110450 WP_005602211.1 NZ_CP031869:1918608-1919075 [Actinobacillus pleuropneumoniae]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL

Download         Length: 468 bp

>T110450 NZ_CP031869:1918608-1919075 [Actinobacillus pleuropneumoniae]
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGAAAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGTGCCTTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGTTCGGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAATCCGCAAGCAAAAC
AATTTTATTTAAAGTACGGTTTTTCATGTTCACCCATTGATGAGATGGTTTTAATGTTAAAACTCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9796.14 Da        Isoelectric Point: 4.4883

>AT110450 WP_005619269.1 NZ_CP031869:1918344-1918604 [Actinobacillus pleuropneumoniae]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Download         Length: 261 bp

>AT110450 NZ_CP031869:1918344-1918604 [Actinobacillus pleuropneumoniae]
ATGAGAACTGCGCCAATTAATTTACGAGCGATGCCTGATCAGCGTGATTTAATTGATTATGCGGCAAGCATTTTAGGTAA
AACACGTTCTGACTTTATGTTAGAAACCGCCTGCCAAGCTGCCCAAAATGTGATTTTAGATCGTACCGTTTTCCAATTAA
ATGAGCAGGCTTTCGAGCAATTTAACCGATTGCTAGAACAGCCAACAGCAGATAATCCGGGGTTAGATAAACTGTTAAAT
ACCAAAGCGGTGTGGGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A448U107

Antitoxin

Source ID Structure
AlphaFold DB A3N2I7

References