Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1484455..1484963 Replicon chromosome
Accession NZ_CP031869
Organism Actinobacillus pleuropneumoniae strain WF83

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D1100_RS06815 Protein ID WP_017357690.1
Coordinates 1484703..1484963 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D1100_RS06810 Protein ID WP_017357689.1
Coordinates 1484455..1484706 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1100_RS06770 (D1100_06815) 1479990..1480538 - 549 WP_005617759.1 type IV pilus biogenesis/stability protein PilW -
D1100_RS06775 (D1100_06820) 1480592..1481773 - 1182 WP_005608495.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
D1100_RS06800 (D1100_06845) 1482678..1484117 + 1440 WP_005605060.1 glutamate--tRNA ligase -
D1100_RS06810 (D1100_06855) 1484455..1484706 + 252 WP_017357689.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
D1100_RS06815 (D1100_06860) 1484703..1484963 + 261 WP_017357690.1 Txe/YoeB family addiction module toxin Toxin
D1100_RS06820 (D1100_06865) 1485122..1485289 - 168 WP_005598320.1 Trm112 family protein -
D1100_RS06825 (D1100_06870) 1485291..1486271 - 981 WP_005598322.1 tetraacyldisaccharide 4'-kinase -
D1100_RS06830 (D1100_06875) 1486365..1487624 - 1260 WP_005598324.1 ATP-dependent protease ATP-binding subunit ClpX -
D1100_RS06835 (D1100_06880) 1487624..1488214 - 591 WP_005601821.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
D1100_RS06840 (D1100_06885) 1488336..1488728 + 393 WP_005620423.1 SufE family protein -
D1100_RS06855 (D1100_06900) 1489087..1489860 - 774 WP_005618837.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10423.94 Da        Isoelectric Point: 8.0109

>T110446 WP_017357690.1 NZ_CP031869:1484703-1484963 [Actinobacillus pleuropneumoniae]
MKLTFSSNSWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKPEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Download         Length: 261 bp

>T110446 NZ_CP031869:1484703-1484963 [Actinobacillus pleuropneumoniae]
ATGAAGCTAACTTTCTCGTCTAATTCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACCGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9336.62 Da        Isoelectric Point: 4.5659

>AT110446 WP_017357689.1 NZ_CP031869:1484455-1484706 [Actinobacillus pleuropneumoniae]
MQAITYTEARQNLAGTMSKVTEDFEPVLITRSKGGNCVLMSYEQYSSLEETAYLMRSPANAQRLLDSMAELKQGKGIERE
LIE

Download         Length: 252 bp

>AT110446 NZ_CP031869:1484455-1484706 [Actinobacillus pleuropneumoniae]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATTTAGCAGGTACAATGTCAAAAGTAACAGAAGATTTTGAACCTGT
TTTAATTACAAGAAGCAAGGGTGGAAATTGCGTACTTATGTCGTATGAGCAGTATAGTTCACTTGAAGAAACCGCCTATT
TAATGCGTTCCCCGGCTAACGCTCAAAGATTACTAGACAGCATGGCAGAATTGAAGCAAGGGAAAGGCATTGAAAGAGAG
CTAATCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References