Detailed information of TA system TA110441

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1564882..1565527
• Replicon: chromosome
• Accession: NZ_CP031866
• Organism: Actinobacillus pleuropneumoniae serovar 8 str. 405

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: B0BQU7
• Locus tag: D1101_RS07265
• Protein ID: WP_005619674.1
• Coordinates: 1565156..1565527 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: D1101_RS07260
• Protein ID: WP_005598477.1
• Coordinates: 1564882..1565175 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1101_RS07230 (D1101_07305)	1560214..1560897	-	684	WP_005601946.1	arginine ABC transporter permease ArtM	-
D1101_RS07235 (D1101_07310)	1560897..1561568	-	672	WP_005601949.1	arginine ABC transporter permease ArtQ	-
D1101_RS07240 (D1101_07315)	1561574..1562293	-	720	WP_005619670.1	transporter substrate-binding domain-containing protein	-
D1101_RS07245 (D1101_07320)	1562313..1563047	-	735	WP_005598473.1	arginine ABC transporter ATP-binding protein ArtP	-
D1101_RS07250 (D1101_07325)	1563272..1563769	-	498	WP_005601953.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
D1101_RS07255 (D1101_07330)	1563842..1564804	+	963	WP_005619672.1	calcium/sodium antiporter	-
D1101_RS07260 (D1101_07335)	1564882..1565175	-	294	WP_005598477.1	helix-turn-helix domain-containing protein	Antitoxin
D1101_RS07265 (D1101_07340)	1565156..1565527	-	372	WP_005619674.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1101_RS07270 (D1101_07345)	1565721..1567472	+	1752	WP_039709264.1	protein-disulfide reductase DsbD	-
D1101_RS07275 (D1101_07350)	1567530..1568099	+	570	WP_005608594.1	elongation factor P hydroxylase	-
D1101_RS07280 (D1101_07355)	1568143..1568997	-	855	WP_005598486.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (32-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 15066.57 Da
• Isoelectric Point: 10.4054

>T110441 WP_005619674.1 NZ_CP031866:c1565527-1565156 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Nucleotide

• Length: 372 bp

>T110441 NZ_CP031866:c1565527-1565156 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTACTAAAAGAACG
GCAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGTCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10935.81 Da
• Isoelectric Point: 10.3120

>AT110441 WP_005598477.1 NZ_CP031866:c1565175-1564882 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Nucleotide

• Length: 294 bp

>AT110441 NZ_CP031866:c1565175-1564882 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTCGGAAATAGCGGAAACTCAGTTTCG
CATACGACTTATTTTAGAAATCATTGAAACCCGTCAGCAGCTCGGTATTTCTCAACGAAAATTGGAGAAATTAAGCGGCG
TAAAACAATCTATGATTGCTCGGGTAGAAAAAGGCTCGGTTAATCCGTCGTTGGCGACGGTATTAAAGTTGCTTGTGCCG
TTGGGGAAAACTTTACAAATCGTACCGTTAGATAAAAACAAAACGGTACGTTAA

Structures

Toxin

• AlphaFold DB: A3N206