Detailed information of TA system TA110439

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 774109..774759
• Replicon: chromosome
• Accession: NZ_CP031866
• Organism: Actinobacillus pleuropneumoniae serovar 8 str. 405

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: B0BNU3
• Locus tag: D1101_RS03655
• Protein ID: WP_005614926.1
• Coordinates: 774109..774498 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B0BNU4
• Locus tag: D1101_RS03660
• Protein ID: WP_005604117.1
• Coordinates: 774499..774759 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1101_RS03640 (D1101_03660)	769679..770875	+	1197	WP_039709067.1	amino acid aminotransferase	-
D1101_RS03645 (D1101_03665)	771055..772341	-	1287	WP_009874699.1	Xaa-Pro aminopeptidase	-
D1101_RS03650 (D1101_03670)	772750..773973	-	1224	WP_039709068.1	ATP-binding protein	-
D1101_RS03655 (D1101_03675)	774109..774498	-	390	WP_005614926.1	type II toxin-antitoxin system VapC family toxin	Toxin
D1101_RS03660 (D1101_03680)	774499..774759	-	261	WP_005604117.1	hypothetical protein	Antitoxin
D1101_RS03665 (D1101_03685)	774893..776914	-	2022	WP_058230468.1	excinuclease ABC subunit UvrB	-
D1101_RS03670 (D1101_03695)	777091..777903	+	813	WP_039709069.1	iron uptake system protein EfeO	-
D1101_RS03675 (D1101_03700)	777915..779108	+	1194	WP_005604123.1	iron uptake transporter deferrochelatase/peroxidase subunit	-
D1101_RS03680 (D1101_03705)	779119..779739	+	621	WP_039709071.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-117)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14837.17 Da
• Isoelectric Point: 5.1295

>T110439 WP_005614926.1 NZ_CP031866:c774498-774109 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
MYMLDTNTVSYFFRQDPTVVKKLQQLNPELICISSVTAAELFYGVKKRNNQKLTAFLNTFLSAITVMDWDYQVAEVYGQL
RAEMEREGKIMGVQDQMIGAHALATECVLVSSDKAFQFIPNLVLENWWK

Nucleotide

• Length: 390 bp

>T110439 NZ_CP031866:c774498-774109 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
ATGTATATGCTAGATACTAATACGGTGAGTTATTTCTTTAGGCAAGATCCTACTGTGGTTAAGAAACTACAACAACTTAA
TCCGGAATTGATTTGTATTTCATCGGTCACGGCTGCAGAGTTGTTTTATGGCGTAAAAAAACGTAATAATCAGAAACTTA
CTGCATTTTTAAATACTTTTTTATCTGCGATTACGGTGATGGATTGGGATTATCAAGTGGCGGAAGTTTATGGTCAGCTG
CGAGCAGAGATGGAACGAGAAGGCAAAATCATGGGCGTTCAAGATCAAATGATTGGAGCTCATGCCCTAGCAACAGAATG
TGTTCTTGTTTCCAGCGATAAAGCCTTTCAATTTATCCCTAATCTCGTATTAGAAAATTGGTGGAAGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10289.63 Da
• Isoelectric Point: 5.1867

>AT110439 WP_005604117.1 NZ_CP031866:c774759-774499 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
MEKVARLFRNGRNQAVRLPVEFEFNAKQVYVFKEANGDITLSTRSRNQQNWQKVFELLPMLECDEQFLSEQERKQEMATR
DPFEGF

Nucleotide

• Length: 261 bp

>AT110439 NZ_CP031866:c774759-774499 [Actinobacillus pleuropneumoniae serovar 8 str. 405]
ATGGAAAAGGTCGCACGTTTATTTAGAAACGGACGTAATCAAGCCGTACGATTACCGGTTGAATTTGAGTTTAATGCGAA
GCAAGTTTATGTGTTTAAAGAAGCAAACGGCGATATTACGCTTTCGACACGTTCTCGCAATCAGCAAAATTGGCAGAAAG
TCTTTGAGTTATTACCAATGCTTGAATGTGATGAACAGTTTTTATCGGAACAAGAACGCAAGCAAGAAATGGCAACTCGA
GATCCGTTCGAGGGCTTTTAA

Structures

Toxin

• AlphaFold DB: A3N029

Antitoxin

• AlphaFold DB: A3N030