Detailed information of TA system TA110438

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1910898..1911526
• Replicon: chromosome
• Accession: NZ_CP031865
• Organism: Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1102_RS09085
• Protein ID: WP_005599242.1
• Coordinates: 1910898..1911296 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A828PGB0
• Locus tag: D1102_RS09090
• Protein ID: WP_005599241.1
• Coordinates: 1911296..1911526 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1102_RS09060 (D1102_09085)	1906087..1906800	+	714	WP_005609162.1	DNA/RNA nuclease SfsA	-
D1102_RS09065 (D1102_09090)	1906878..1907399	+	522	WP_005599247.1	ATP-dependent protease subunit HslV	-
D1102_RS09070 (D1102_09095)	1907545..1908867	+	1323	WP_005620148.1	HslU--HslV peptidase ATPase subunit	-
D1102_RS09075 (D1102_09100)	1908920..1910110	+	1191	WP_005599245.1	pentapeptide repeat-containing protein	-
D1102_RS09080 (D1102_09105)	1910347..1910763	+	417	WP_005599244.1	DUF417 family protein	-
D1102_RS09085 (D1102_09110)	1910898..1911296	-	399	WP_005599242.1	tRNA(fMet)-specific endonuclease VapC	Toxin
D1102_RS09090 (D1102_09115)	1911296..1911526	-	231	WP_005599241.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
D1102_RS09095	1911601..1911774	+	174	Protein_1749	addiction module antidote protein, HigA family	-
D1102_RS09100 (D1102_09120)	1911967..1913553	-	1587	WP_005599240.1	DUF262 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1910347..1927170	16823

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (6-52)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15028.31 Da
• Isoelectric Point: 7.4716

>T110438 WP_005599242.1 NZ_CP031865:c1911296-1910898 [Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261]
MLTYMLDTNIAIYVIKRRPLEVLDKFNLNSTRLCVSSITAAELYYGAEKSQFPEQNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKHGKIIGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLANWV

Nucleotide

• Length: 399 bp

>T110438 NZ_CP031865:c1911296-1910898 [Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261]
ATGCTGACTTATATGCTTGATACTAACATTGCGATTTATGTCATTAAACGCAGACCACTTGAAGTGCTGGATAAGTTTAA
TTTAAATTCCACCCGTCTTTGTGTAAGTAGTATCACTGCAGCGGAGCTGTATTATGGGGCAGAGAAAAGCCAGTTTCCGG
AACAGAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGCGGCTACTCACTTT
GGCAATATCAAAGCACATTTATCTAAGCACGGTAAGATTATCGGGGAGAACGATATTCACATTGCCGCACATGCAAGAAG
TGAAGGACTCGTATTAGTAACCAATAACTTGCGTGAATTTGAACGTGTGGAAGGATTACGATTAGCTAATTGGGTATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8561.71 Da
• Isoelectric Point: 4.7063

>AT110438 WP_005599241.1 NZ_CP031865:c1911526-1911296 [Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLGSATVSDDFMTEREISIQPEREGL

Nucleotide

• Length: 231 bp

>AT110438 NZ_CP031865:c1911526-1911296 [Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261]
ATGGAAGCATCGGTATTTATGACAAACCGTAGTCAAGCGGTACGATTGCCGGCAGAAGTACGCTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTAGTCGGTAATGAGCGTATTTTGGCTCCGATTAACCAAAGTTGGGATAGCTTCTTTCTGGGGT
CGGCAACGGTAAGCGATGATTTCATGACAGAGCGTGAAATCAGCATTCAGCCCGAACGTGAGGGACTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A828PGB0