Detailed information of TA system TA110437

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-YefM
• Location: 1827679..1828394
• Replicon: chromosome
• Accession: NZ_CP031865
• Organism: Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1102_RS08585
• Protein ID: WP_005599445.1
• Coordinates: 1828029..1828394 (+)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B0BT01
• Locus tag: D1102_RS08580
• Protein ID: WP_005599447.1
• Coordinates: 1827679..1827966 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1102_RS08555 (D1102_08570)	1823282..1823875	-	594	WP_005599453.1	protein-methionine-sulfoxide reductase heme-binding subunit MsrQ	-
D1102_RS08560 (D1102_08575)	1823875..1824831	-	957	WP_005619040.1	protein-methionine-sulfoxide reductase catalytic subunit MsrP	-
D1102_RS08565 (D1102_08580)	1824920..1825501	+	582	WP_005599450.1	sigma-70 family RNA polymerase sigma factor	-
D1102_RS08570 (D1102_08585)	1825504..1825692	+	189	WP_005602684.1	hypothetical protein	-
D1102_RS08575 (D1102_08590)	1825758..1827473	-	1716	WP_005599448.1	proline--tRNA ligase	-
D1102_RS08580 (D1102_08595)	1827679..1827966	+	288	WP_005599447.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D1102_RS08585 (D1102_08600)	1828029..1828394	+	366	WP_005599445.1	type II toxin-antitoxin system VapC family toxin	Toxin
D1102_RS08590 (D1102_08605)	1828518..1830599	+	2082	WP_005599444.1	ATP-dependent DNA helicase RecG	-
D1102_RS08595 (D1102_08610)	1830726..1831007	+	282	WP_005599441.1	DNA-directed RNA polymerase subunit omega	-
D1102_RS08600 (D1102_08615)	1831103..1832809	+	1707	WP_005599433.1	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13974.06 Da
• Isoelectric Point: 9.0549

>T110437 WP_005599445.1 NZ_CP031865:1828029-1828394 [Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261]
MDTNVRQWLATIKPSQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHNVLSVYQAKSFSINNEIALLASEYHIPNK
MDLNDAYIAATAKYHNLVLVTRNLKDFNRCDIRLFNPFEPN

Nucleotide

• Length: 366 bp

>T110437 NZ_CP031865:1828029-1828394 [Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261]
ATGGATACCAATGTACGACAATGGTTAGCAACGATTAAACCGAGTCAGACGAATATTAGCTGTATCACGCTTTCCGAAAT
AAAAACGGGGATTTTACTCAAAGCTCGTAAAGATCCTATTCAAGCCGAGCGGTTAAATCATTGGTTTACCCATAATGTAT
TAAGCGTTTATCAAGCTAAATCCTTTTCTATAAATAATGAAATTGCGTTACTGGCTTCTGAATACCACATTCCAAATAAA
ATGGATTTAAACGATGCTTATATTGCCGCAACCGCTAAATATCATAATTTAGTGCTTGTTACTCGTAATTTGAAAGACTT
CAACCGTTGCGATATACGTTTATTTAATCCTTTCGAACCGAATTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11040.29 Da
• Isoelectric Point: 4.5578

>AT110437 WP_005599447.1 NZ_CP031865:1827679-1827966 [Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261]
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE

Nucleotide

• Length: 288 bp

>AT110437 NZ_CP031865:1827679-1827966 [Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261]
ATGCCAATTACTATTACCTCTCGAGAATTTAATCAACACGCCAGTAAAGTGCTGAAAATGGCAGAAAAAGAACCGGTTTT
TATCACTAAATGGGGAAAAATTGTCAGCGTTGTCTCCAATTATGTTGATTACAAACAGCACACAACGGTTGAGCCTAGCT
TTGAAGAACTATTTGCCTCATCTACGGATGAATCGGTTAGCGATGAGTTTTGGCAAGATTTTGAACAGACATTAACAAAA
ATTCGCAAAAGTAATAAATCCGAACAAATAGATTTTGGAGATGAATAA

Structures

Antitoxin

• AlphaFold DB: A3N3C5