Detailed information of TA system TA110434

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 1509745..1510253
• Replicon: chromosome
• Accession: NZ_CP031865
• Organism: Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0BQK9
• Locus tag: D1102_RS06965
• Protein ID: WP_005605064.1
• Coordinates: 1509993..1510253 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D1102_RS06960
• Protein ID: WP_005610475.1
• Coordinates: 1509745..1509996 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1102_RS06920 (D1102_06935)	1505282..1505830	-	549	WP_005598298.1	type IV pilus biogenesis/stability protein PilW	-
D1102_RS06925 (D1102_06940)	1505884..1507065	-	1182	WP_005598300.1	bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN	-
D1102_RS06950 (D1102_06965)	1507969..1509408	+	1440	WP_005598316.1	glutamate--tRNA ligase	-
D1102_RS06960 (D1102_06975)	1509745..1509996	+	252	WP_005610475.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
D1102_RS06965 (D1102_06980)	1509993..1510253	+	261	WP_005605064.1	Txe/YoeB family addiction module toxin	Toxin
D1102_RS06970 (D1102_06985)	1510412..1510579	-	168	WP_005598320.1	Trm112 family protein	-
D1102_RS06975 (D1102_06990)	1510581..1511561	-	981	WP_005598322.1	tetraacyldisaccharide 4'-kinase	-
D1102_RS06980 (D1102_06995)	1511655..1512914	-	1260	WP_005598324.1	ATP-dependent protease ATP-binding subunit ClpX	-
D1102_RS06985 (D1102_07000)	1512914..1513504	-	591	WP_005598326.1	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	-
D1102_RS06990 (D1102_07005)	1513626..1514018	+	393	WP_005620423.1	SufE family protein	-
D1102_RS07005 (D1102_07020)	1514377..1515150	-	774	WP_005598329.1	DNA polymerase III subunit epsilon	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10423.99 Da
• Isoelectric Point: 8.0109

>T110434 WP_005605064.1 NZ_CP031865:1509993-1510253 [Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261]
MKLTFSSNAWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKLEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Nucleotide

• Length: 261 bp

>T110434 NZ_CP031865:1509993-1510253 [Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261]
ATGAAGCTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACTGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9374.72 Da
• Isoelectric Point: 4.5659

>AT110434 WP_005610475.1 NZ_CP031865:1509745-1509996 [Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261]
MQAITYTEARQNLAGTMSKVAEDFEPILIIRSKGGNCVLMSYEQYCSLEETAYLMRSPTNAKRLLDSVAELRQGQGIERE
LIE

Nucleotide

• Length: 252 bp

>AT110434 NZ_CP031865:1509745-1509996 [Actinobacillus pleuropneumoniae serovar 9 str. CVJ13261]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACGATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTATAAGAAGCAAGGGCGGAAATTGCGTACTTATGTCGTATGAGCAGTATTGTTCACTTGAAGAAACCGCCTATT
TGATGCGTTCACCCACCAATGCAAAACGGCTATTGGATAGTGTGGCGGAATTAAGACAGGGACAAGGCATTGAAAGAGAG
CTAATCGAATGA

Structures

Toxin

• AlphaFold DB: B0BQK9