Detailed information of TA system TA110433

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-YefM
• Location: 2082478..2083193
• Replicon: chromosome
• Accession: NZ_CP031864
• Organism: Actinobacillus pleuropneumoniae serovar 10 str. D13039

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1103_RS09825
• Protein ID: WP_005606490.1
• Coordinates: 2082478..2082843 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B0BT01
• Locus tag: D1103_RS09830
• Protein ID: WP_005599447.1
• Coordinates: 2082906..2083193 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1103_RS09810 (D1103_09890)	2078063..2079769	-	1707	WP_005606484.1	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	-
D1103_RS09815 (D1103_09895)	2079865..2080146	-	282	WP_005613378.1	DNA-directed RNA polymerase subunit omega	-
D1103_RS09820 (D1103_09900)	2080273..2082354	-	2082	WP_005613379.1	ATP-dependent DNA helicase RecG	-
D1103_RS09825 (D1103_09905)	2082478..2082843	-	366	WP_005606490.1	type II toxin-antitoxin system VapC family toxin	Toxin
D1103_RS09830 (D1103_09910)	2082906..2083193	-	288	WP_005599447.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D1103_RS09835 (D1103_09915)	2083399..2085114	+	1716	WP_005613382.1	proline--tRNA ligase	-
D1103_RS09840 (D1103_09920)	2085180..2085368	-	189	WP_005602684.1	hypothetical protein	-
D1103_RS09845 (D1103_09925)	2085371..2085952	-	582	WP_005606496.1	sigma-70 family RNA polymerase sigma factor	-
D1103_RS09850 (D1103_09930)	2086041..2086997	+	957	WP_005619040.1	protein-methionine-sulfoxide reductase catalytic subunit MsrP	-
D1103_RS09855 (D1103_09935)	2086997..2087590	+	594	WP_005599453.1	protein-methionine-sulfoxide reductase heme-binding subunit MsrQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-103)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13921.01 Da
• Isoelectric Point: 8.2783

>T110433 WP_005606490.1 NZ_CP031864:c2082843-2082478 [Actinobacillus pleuropneumoniae serovar 10 str. D13039]
MDTNVRQWLATIKPSQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHNVLSVYQAKSFSINNEIALLASEYHIPNK
MDLNDAYIAATAKYHNLVLVTRNLKDFNCCDIRLFNPFEPN

Nucleotide

• Length: 366 bp

>T110433 NZ_CP031864:c2082843-2082478 [Actinobacillus pleuropneumoniae serovar 10 str. D13039]
ATGGATACCAATGTACGACAATGGTTAGCAACGATTAAACCGAGTCAGACGAATATTAGCTGTATCACGCTTTCCGAAAT
AAAAACGGGGATTTTACTCAAAGCTCGTAAAGATCCTATTCAAGCCGAGCGGTTAAATCATTGGTTTACCCATAATGTAT
TAAGCGTTTATCAAGCTAAATCCTTTTCTATAAATAATGAAATTGCGTTACTGGCTTCTGAATACCACATTCCAAATAAA
ATGGATTTAAACGATGCTTATATTGCCGCAACCGCTAAATATCATAATTTAGTGCTTGTTACTCGTAATTTGAAAGACTT
CAACTGTTGCGATATACGTTTATTTAATCCTTTCGAACCGAATTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11040.29 Da
• Isoelectric Point: 4.5578

>AT110433 WP_005599447.1 NZ_CP031864:c2083193-2082906 [Actinobacillus pleuropneumoniae serovar 10 str. D13039]
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE

Nucleotide

• Length: 288 bp

>AT110433 NZ_CP031864:c2083193-2082906 [Actinobacillus pleuropneumoniae serovar 10 str. D13039]
ATGCCAATTACTATTACCTCTCGAGAATTTAATCAACACGCCAGTAAAGTGCTGAAAATGGCAGAAAAAGAACCGGTTTT
TATCACTAAATGGGGAAAAATTGTCAGCGTTGTCTCCAATTATGTTGATTACAAACAGCACACAACGGTTGAGCCTAGCT
TTGAAGAACTATTTGCCTCATCTACGGATGAATCGGTTAGCGATGAGTTTTGGCAAGATTTTGAACAGACATTAACAAAA
ATTCGCAAAAGTAATAAATCCGAACAAATAGATTTTGGAGATGAATAA

Structures

Antitoxin

• AlphaFold DB: A3N3C5