Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1765230..1765961 | Replicon | chromosome |
| Accession | NZ_CP031864 | ||
| Organism | Actinobacillus pleuropneumoniae serovar 10 str. D13039 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | A0A448U107 |
| Locus tag | D1103_RS08155 | Protein ID | WP_005602211.1 |
| Coordinates | 1765230..1765697 (-) | Length | 156 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | B0BRD3 |
| Locus tag | D1103_RS08160 | Protein ID | WP_005619269.1 |
| Coordinates | 1765701..1765961 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D1103_RS08130 (D1103_08195) | 1760588..1760959 | - | 372 | WP_005598830.1 | CrcB family protein | - |
| D1103_RS08135 (D1103_08200) | 1760962..1762026 | - | 1065 | WP_043995144.1 | MFS transporter | - |
| D1103_RS08140 (D1103_08205) | 1762121..1763230 | + | 1110 | WP_005613081.1 | anhydro-N-acetylmuramic acid kinase | - |
| D1103_RS08145 (D1103_08210) | 1763284..1764198 | + | 915 | WP_005613083.1 | N-acetylmuramic acid 6-phosphate etherase | - |
| D1103_RS08150 (D1103_08215) | 1764265..1765146 | - | 882 | WP_043995145.1 | 50S ribosomal protein L11 methyltransferase | - |
| D1103_RS08155 (D1103_08220) | 1765230..1765697 | - | 468 | WP_005602211.1 | GNAT family N-acetyltransferase | Toxin |
| D1103_RS08160 (D1103_08225) | 1765701..1765961 | - | 261 | WP_005619269.1 | DUF1778 domain-containing protein | Antitoxin |
| D1103_RS08165 (D1103_08230) | 1766082..1767542 | - | 1461 | WP_005613087.1 | metalloprotease TldD | - |
| D1103_RS08170 (D1103_08235) | 1767672..1768931 | + | 1260 | WP_005613089.1 | tRNA lysidine(34) synthetase TilS | - |
| D1103_RS08175 (D1103_08240) | 1769049..1769837 | - | 789 | WP_005613624.1 | transposase | - |
| D1103_RS08180 (D1103_08245) | 1770056..1770346 | - | 291 | WP_005613091.1 | DUF5389 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 156 a.a. Molecular weight: 17192.19 Da Isoelectric Point: 8.9312
>T110430 WP_005602211.1 NZ_CP031864:c1765697-1765230 [Actinobacillus pleuropneumoniae serovar 10 str. D13039]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL
Download Length: 468 bp
>T110430 NZ_CP031864:c1765697-1765230 [Actinobacillus pleuropneumoniae serovar 10 str. D13039]
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGAAAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGTGCCTTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGTTCGGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAATCCGCAAGCAAAAC
AATTTTATTTAAAGTACGGTTTTTCATGTTCACCCATTGATGAGATGGTTTTAATGTTAAAACTCTAA
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGAAAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGTGCCTTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGTTCGGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAATCCGCAAGCAAAAC
AATTTTATTTAAAGTACGGTTTTTCATGTTCACCCATTGATGAGATGGTTTTAATGTTAAAACTCTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9796.14 Da Isoelectric Point: 4.4883
>AT110430 WP_005619269.1 NZ_CP031864:c1765961-1765701 [Actinobacillus pleuropneumoniae serovar 10 str. D13039]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE
Download Length: 261 bp
>AT110430 NZ_CP031864:c1765961-1765701 [Actinobacillus pleuropneumoniae serovar 10 str. D13039]
ATGAGAACTGCGCCAATTAATTTACGAGCGATGCCTGATCAGCGTGATTTAATTGATTATGCGGCAAGCATTTTAGGTAA
AACACGTTCTGACTTTATGTTAGAAACCGCCTGCCAAGCTGCCCAAAATGTGATTTTAGATCGTACCGTTTTCCAATTAA
ATGAGCAGGCTTTCGAGCAATTTAACCGATTGCTAGAACAGCCAACAGCAGATAATCCGGGGTTAGATAAACTGTTAAAT
ACCAAAGCGGTGTGGGAGTAG
ATGAGAACTGCGCCAATTAATTTACGAGCGATGCCTGATCAGCGTGATTTAATTGATTATGCGGCAAGCATTTTAGGTAA
AACACGTTCTGACTTTATGTTAGAAACCGCCTGCCAAGCTGCCCAAAATGTGATTTTAGATCGTACCGTTTTCCAATTAA
ATGAGCAGGCTTTCGAGCAATTTAACCGATTGCTAGAACAGCCAACAGCAGATAATCCGGGGTTAGATAAACTGTTAAAT
ACCAAAGCGGTGTGGGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A448U107 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A3N2I7 |