Detailed information of TA system TA110429

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1567479..1568124
• Replicon: chromosome
• Accession: NZ_CP031864
• Organism: Actinobacillus pleuropneumoniae serovar 10 str. D13039

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: B0BQU7
• Locus tag: D1103_RS07180
• Protein ID: WP_005619674.1
• Coordinates: 1567753..1568124 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: D1103_RS07175
• Protein ID: WP_005598477.1
• Coordinates: 1567479..1567772 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1103_RS07145 (D1103_07215)	1562811..1563494	-	684	WP_005605188.1	arginine ABC transporter permease ArtM	-
D1103_RS07150 (D1103_07220)	1563494..1564165	-	672	WP_005612835.1	arginine ABC transporter permease ArtQ	-
D1103_RS07155 (D1103_07225)	1564171..1564890	-	720	WP_043995135.1	transporter substrate-binding domain-containing protein	-
D1103_RS07160 (D1103_07230)	1564910..1565644	-	735	WP_005612838.1	arginine ABC transporter ATP-binding protein ArtP	-
D1103_RS07165 (D1103_07235)	1565869..1566366	-	498	WP_005612841.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
D1103_RS07170 (D1103_07240)	1566439..1567401	+	963	WP_005619672.1	calcium/sodium antiporter	-
D1103_RS07175 (D1103_07245)	1567479..1567772	-	294	WP_005598477.1	helix-turn-helix domain-containing protein	Antitoxin
D1103_RS07180 (D1103_07250)	1567753..1568124	-	372	WP_005619674.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1103_RS07185 (D1103_07255)	1568318..1570069	+	1752	WP_005612846.1	protein-disulfide reductase DsbD	-
D1103_RS07190 (D1103_07260)	1570127..1570696	+	570	WP_005601959.1	elongation factor P hydroxylase	-
D1103_RS07195 (D1103_07265)	1570740..1571594	-	855	WP_005598486.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (32-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 15066.57 Da
• Isoelectric Point: 10.4054

>T110429 WP_005619674.1 NZ_CP031864:c1568124-1567753 [Actinobacillus pleuropneumoniae serovar 10 str. D13039]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Nucleotide

• Length: 372 bp

>T110429 NZ_CP031864:c1568124-1567753 [Actinobacillus pleuropneumoniae serovar 10 str. D13039]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTACTAAAAGAACG
GCAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGTCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10935.81 Da
• Isoelectric Point: 10.3120

>AT110429 WP_005598477.1 NZ_CP031864:c1567772-1567479 [Actinobacillus pleuropneumoniae serovar 10 str. D13039]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Nucleotide

• Length: 294 bp

>AT110429 NZ_CP031864:c1567772-1567479 [Actinobacillus pleuropneumoniae serovar 10 str. D13039]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTCGGAAATAGCGGAAACTCAGTTTCG
CATACGACTTATTTTAGAAATCATTGAAACCCGTCAGCAGCTCGGTATTTCTCAACGAAAATTGGAGAAATTAAGCGGCG
TAAAACAATCTATGATTGCTCGGGTAGAAAAAGGCTCGGTTAATCCGTCGTTGGCGACGGTATTAAAGTTGCTTGTGCCG
TTGGGGAAAACTTTACAAATCGTACCGTTAGATAAAAACAAAACGGTACGTTAA

Structures

Toxin

• AlphaFold DB: A3N206