Detailed information of TA system TA110424

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1595430..1596075
• Replicon: chromosome
• Accession: NZ_CP031863
• Organism: Actinobacillus pleuropneumoniae serovar 11 str. 56153

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: B0BQU7
• Locus tag: D1104_RS07425
• Protein ID: WP_005619674.1
• Coordinates: 1595704..1596075 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: D1104_RS07420
• Protein ID: WP_005598477.1
• Coordinates: 1595430..1595723 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1104_RS07390 (D1104_07430)	1590771..1591454	-	684	WP_005610526.1	arginine ABC transporter permease ArtM	-
D1104_RS07395 (D1104_07435)	1591454..1592125	-	672	WP_005610527.1	arginine ABC transporter permease ArtQ	-
D1104_RS07400 (D1104_07440)	1592131..1592850	-	720	WP_043993302.1	transporter substrate-binding domain-containing protein	-
D1104_RS07405 (D1104_07445)	1592870..1593604	-	735	WP_005598473.1	arginine ABC transporter ATP-binding protein ArtP	-
D1104_RS07410 (D1104_07450)	1593829..1594326	-	498	WP_005601953.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
D1104_RS07415 (D1104_07455)	1594399..1595352	+	954	WP_043991874.1	calcium/sodium antiporter	-
D1104_RS07420 (D1104_07460)	1595430..1595723	-	294	WP_005598477.1	helix-turn-helix domain-containing protein	Antitoxin
D1104_RS07425 (D1104_07465)	1595704..1596075	-	372	WP_005619674.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1104_RS07430 (D1104_07470)	1596269..1598020	+	1752	WP_005598482.1	protein-disulfide reductase DsbD	-
D1104_RS07435 (D1104_07475)	1598078..1598647	+	570	WP_005598484.1	elongation factor P hydroxylase	-
D1104_RS07440 (D1104_07480)	1598691..1599545	-	855	WP_005598486.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (32-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 15066.57 Da
• Isoelectric Point: 10.4054

>T110424 WP_005619674.1 NZ_CP031863:c1596075-1595704 [Actinobacillus pleuropneumoniae serovar 11 str. 56153]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Nucleotide

• Length: 372 bp

>T110424 NZ_CP031863:c1596075-1595704 [Actinobacillus pleuropneumoniae serovar 11 str. 56153]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTACTAAAAGAACG
GCAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGTCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10935.81 Da
• Isoelectric Point: 10.3120

>AT110424 WP_005598477.1 NZ_CP031863:c1595723-1595430 [Actinobacillus pleuropneumoniae serovar 11 str. 56153]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Nucleotide

• Length: 294 bp

>AT110424 NZ_CP031863:c1595723-1595430 [Actinobacillus pleuropneumoniae serovar 11 str. 56153]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTCGGAAATAGCGGAAACTCAGTTTCG
CATACGGCTTATTTTAGAAATCATTGAAACCCGTCAGCAGCTCGGTATCTCTCAACGAAAATTGGAGAAATTAAGCGGCG
TAAAACAATCTATGATTGCTCGGGTAGAAAAAGGCTCGGTTAATCCGTCGTTGGCGACGGTATTAAAGTTGCTTGTGCCG
TTGGGGAAAACTTTACAAATCGTACCGTTAGATAAAAACAAAACGGTACGTTAA

Structures

Toxin

• AlphaFold DB: A3N206