Detailed information of TA system TA110419

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1516138..1516783
• Replicon: chromosome
• Accession: NZ_CP031862
• Organism: Actinobacillus pleuropneumoniae strain 8329

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: B0BQU7
• Locus tag: D1105_RS06895
• Protein ID: WP_005619674.1
• Coordinates: 1516412..1516783 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: D1105_RS06890
• Protein ID: WP_005598477.1
• Coordinates: 1516138..1516431 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1105_RS06860 (D1105_06915)	1511470..1512153	-	684	WP_005601946.1	arginine ABC transporter permease ArtM	-
D1105_RS06865 (D1105_06920)	1512153..1512824	-	672	WP_005615757.1	arginine ABC transporter permease ArtQ	-
D1105_RS06870 (D1105_06925)	1512830..1513549	-	720	WP_043995135.1	transporter substrate-binding domain-containing protein	-
D1105_RS06875 (D1105_06930)	1513569..1514303	-	735	WP_005615759.1	arginine ABC transporter ATP-binding protein ArtP	-
D1105_RS06880 (D1105_06935)	1514528..1515025	-	498	WP_005615760.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
D1105_RS06885 (D1105_06940)	1515098..1516060	+	963	WP_005619672.1	calcium/sodium antiporter	-
D1105_RS06890 (D1105_06945)	1516138..1516431	-	294	WP_005598477.1	helix-turn-helix domain-containing protein	Antitoxin
D1105_RS06895 (D1105_06950)	1516412..1516783	-	372	WP_005619674.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1105_RS06900 (D1105_06955)	1516977..1518728	+	1752	WP_005615762.1	protein-disulfide reductase DsbD	-
D1105_RS06905 (D1105_06960)	1518786..1519355	+	570	WP_005615764.1	elongation factor P hydroxylase	-
D1105_RS06910 (D1105_06965)	1519399..1520253	-	855	WP_005615766.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (32-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 15066.57 Da
• Isoelectric Point: 10.4054

>T110419 WP_005619674.1 NZ_CP031862:c1516783-1516412 [Actinobacillus pleuropneumoniae]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Nucleotide

• Length: 372 bp

>T110419 NZ_CP031862:c1516783-1516412 [Actinobacillus pleuropneumoniae]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTACTAAAAGAACG
GCAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGTCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10935.81 Da
• Isoelectric Point: 10.3120

>AT110419 WP_005598477.1 NZ_CP031862:c1516431-1516138 [Actinobacillus pleuropneumoniae]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Nucleotide

• Length: 294 bp

>AT110419 NZ_CP031862:c1516431-1516138 [Actinobacillus pleuropneumoniae]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTCGGAAATAGCGGAAACTCAGTTTCG
CATACGACTTATTTTAGAAATCATTGAAACCCGTCAGCAGCTCGGTATTTCTCAACGAAAATTGGAGAAATTAAGCGGCG
TAAAACAATCTATGATTGCTCGGGTAGAAAAAGGCTCGGTTAATCCGTCGTTGGCGACGGTATTAAAGTTGCTTGTGCCG
TTGGGGAAAACTTTACAAATCGTACCGTTAGATAAAAACAAAACGGTACGTTAA

Structures

Toxin

• AlphaFold DB: A3N206