Detailed information of TA system TA110416

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-YefM
• Location: 2082848..2083563
• Replicon: chromosome
• Accession: NZ_CP031861
• Organism: Actinobacillus pleuropneumoniae strain N 273

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1106_RS09905
• Protein ID: WP_005606490.1
• Coordinates: 2082848..2083213 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B0BT01
• Locus tag: D1106_RS09910
• Protein ID: WP_005599447.1
• Coordinates: 2083276..2083563 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1106_RS09890 (D1106_09935)	2078433..2080139	-	1707	WP_237593915.1	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	-
D1106_RS09895 (D1106_09940)	2080235..2080516	-	282	WP_005599441.1	DNA-directed RNA polymerase subunit omega	-
D1106_RS09900 (D1106_09945)	2080643..2082724	-	2082	WP_005606488.1	ATP-dependent DNA helicase RecG	-
D1106_RS09905 (D1106_09950)	2082848..2083213	-	366	WP_005606490.1	type II toxin-antitoxin system VapC family toxin	Toxin
D1106_RS09910 (D1106_09955)	2083276..2083563	-	288	WP_005599447.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D1106_RS09915 (D1106_09960)	2083769..2085484	+	1716	WP_237593916.1	proline--tRNA ligase	-
D1106_RS09920 (D1106_09965)	2085550..2085738	-	189	WP_005602684.1	hypothetical protein	-
D1106_RS09925 (D1106_09970)	2085741..2086322	-	582	WP_005606496.1	sigma-70 family RNA polymerase sigma factor	-
D1106_RS09930 (D1106_09975)	2086411..2087367	+	957	WP_005619040.1	protein-methionine-sulfoxide reductase catalytic subunit MsrP	-
D1106_RS09935 (D1106_09980)	2087367..2087960	+	594	WP_005599453.1	protein-methionine-sulfoxide reductase heme-binding subunit MsrQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-103)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13921.01 Da
• Isoelectric Point: 8.2783

>T110416 WP_005606490.1 NZ_CP031861:c2083213-2082848 [Actinobacillus pleuropneumoniae]
MDTNVRQWLATIKPSQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHNVLSVYQAKSFSINNEIALLASEYHIPNK
MDLNDAYIAATAKYHNLVLVTRNLKDFNCCDIRLFNPFEPN

Nucleotide

• Length: 366 bp

>T110416 NZ_CP031861:c2083213-2082848 [Actinobacillus pleuropneumoniae]
ATGGATACCAATGTACGACAATGGTTAGCAACGATTAAACCGAGTCAGACGAATATTAGCTGTATCACGCTTTCCGAAAT
AAAAACGGGGATTTTACTCAAAGCTCGTAAAGATCCTATTCAAGCCGAGCGGTTAAATCATTGGTTTACCCATAATGTAT
TAAGCGTTTATCAAGCTAAATCCTTTTCTATAAATAATGAAATTGCGTTACTGGCTTCTGAATACCACATTCCAAATAAA
ATGGATTTAAACGATGCTTATATTGCCGCAACCGCTAAATATCATAATTTAGTGCTTGTTACTCGTAATTTGAAAGACTT
CAACTGTTGCGATATACGTTTATTTAATCCTTTCGAACCGAATTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11040.29 Da
• Isoelectric Point: 4.5578

>AT110416 WP_005599447.1 NZ_CP031861:c2083563-2083276 [Actinobacillus pleuropneumoniae]
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE

Nucleotide

• Length: 288 bp

>AT110416 NZ_CP031861:c2083563-2083276 [Actinobacillus pleuropneumoniae]
ATGCCAATTACTATTACCTCTCGAGAATTTAATCAACACGCCAGTAAAGTGCTGAAAATGGCAGAAAAAGAACCGGTTTT
TATCACTAAATGGGGAAAAATTGTCAGCGTTGTCTCCAATTATGTTGATTACAAACAGCACACAACGGTTGAGCCTAGCT
TTGAAGAACTATTTGCCTCATCTACGGATGAATCGGTTAGCGATGAGTTTTGGCAAGATTTTGAACAGACATTAACAAAA
ATTCGCAAAAGTAATAAATCCGAACAAATAGATTTTGGAGATGAATAA

Structures

Antitoxin

• AlphaFold DB: A3N3C5