Detailed information of TA system TA110415

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1981377..1982005
• Replicon: chromosome
• Accession: NZ_CP031861
• Organism: Actinobacillus pleuropneumoniae strain N 273

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1106_RS09310
• Protein ID: WP_237593890.1
• Coordinates: 1981607..1982005 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: D1106_RS09305
• Protein ID: WP_237593889.1
• Coordinates: 1981377..1981607 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1106_RS09295 (D1106_09335)	1979626..1980024	+	399	WP_237593887.1	hypothetical protein	-
D1106_RS09300 (D1106_09340)	1980021..1981037	+	1017	WP_237593888.1	hypothetical protein	-
D1106_RS09305 (D1106_09345)	1981377..1981607	+	231	WP_237593889.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
D1106_RS09310 (D1106_09350)	1981607..1982005	+	399	WP_237593890.1	tRNA(fMet)-specific endonuclease VapC	Toxin
D1106_RS09315 (D1106_09355)	1982140..1982556	-	417	WP_215577975.1	DUF417 family protein	-
D1106_RS09320 (D1106_09360)	1982802..1983452	+	651	WP_237593891.1	DUF2202 domain-containing protein	-
D1106_RS09325 (D1106_09365)	1983632..1984411	-	780	WP_005613304.1	hypothetical protein	-
D1106_RS09330 (D1106_09370)	1984484..1985806	-	1323	WP_005620148.1	HslU--HslV peptidase ATPase subunit	-
D1106_RS09335 (D1106_09375)	1985953..1986474	-	522	WP_005618211.1	ATP-dependent protease subunit HslV	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1967337..2017019	49682

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (6-52)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15036.35 Da
• Isoelectric Point: 7.3824

>T110415 WP_237593890.1 NZ_CP031861:1981607-1982005 [Actinobacillus pleuropneumoniae]
MLAYMLDTNIAIYVIKRRPIEVLDKFNLNSTRLCVSSITAAELYYGAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKCGKILGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLDNWV

Nucleotide

• Length: 399 bp

>T110415 NZ_CP031861:1981607-1982005 [Actinobacillus pleuropneumoniae]
ATGCTGGCTTATATGCTTGATACTAATATTGCGATTTATGTGATTAAACGCAGACCTATTGAAGTGCTGGATAAGTTTAA
TTTAAATTCCACTCGTCTTTGCGTGAGTAGTATTACAGCGGCTGAGTTATATTATGGTGCAGAGAAAAGCCAGTTTCCGG
AACGAAATATGGCAGTCATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGCGGCTACTCACTTT
GGCAATATTAAAGCACATTTATCTAAGTGCGGTAAGATTCTCGGCGAGAACGATATTCATATTGCCGCGCATGCAAGAAG
TGAAGGACTCGTATTAGTAACCAATAACTTACGTGAATTTGAACGTGTAGAAGGATTGCGATTAGATAATTGGGTATAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8639.73 Da
• Isoelectric Point: 4.5358

>AT110415 WP_237593889.1 NZ_CP031861:1981377-1981607 [Actinobacillus pleuropneumoniae]
MEASVFMTNRSQAVRLPVEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLGSSTVSDDFMTEREISTQAEREEL

Nucleotide

• Length: 231 bp

>AT110415 NZ_CP031861:1981377-1981607 [Actinobacillus pleuropneumoniae]
ATGGAAGCATCAGTATTTATGACAAACCGTAGTCAAGCGGTACGATTACCTGTGGAAGTGCGTTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTAGTCGGTAATGAACGTATTTTGGCTCCGATTAACCAAAGTTGGGATAGCTTCTTTCTGGGTT
CGTCAACGGTAAGCGATGATTTTATGACAGAGCGTGAAATCAGCACTCAAGCCGAACGTGAGGAACTGTAA