Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1760325..1761056 Replicon chromosome
Accession NZ_CP031861
Organism Actinobacillus pleuropneumoniae strain N 273

Toxin (Protein)


Gene name tacT Uniprot ID A0A448U107
Locus tag D1106_RS08215 Protein ID WP_005602211.1
Coordinates 1760325..1760792 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID B0BRD3
Locus tag D1106_RS08220 Protein ID WP_005619269.1
Coordinates 1760796..1761056 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1106_RS08190 (D1106_08220) 1755683..1756054 - 372 WP_005598830.1 CrcB family protein -
D1106_RS08195 (D1106_08225) 1756057..1757121 - 1065 WP_043990971.1 MFS transporter -
D1106_RS08200 (D1106_08230) 1757216..1758325 + 1110 WP_237593819.1 anhydro-N-acetylmuramic acid kinase -
D1106_RS08205 (D1106_08235) 1758379..1759293 + 915 WP_005602207.1 N-acetylmuramic acid 6-phosphate etherase -
D1106_RS08210 (D1106_08240) 1759360..1760241 - 882 WP_237593820.1 50S ribosomal protein L11 methyltransferase -
D1106_RS08215 (D1106_08245) 1760325..1760792 - 468 WP_005602211.1 GNAT family N-acetyltransferase Toxin
D1106_RS08220 (D1106_08250) 1760796..1761056 - 261 WP_005619269.1 DUF1778 domain-containing protein Antitoxin
D1106_RS08225 (D1106_08255) 1761177..1762637 - 1461 WP_237593821.1 metalloprotease TldD -
D1106_RS08230 (D1106_08260) 1762767..1764026 + 1260 WP_005615928.1 tRNA lysidine(34) synthetase TilS -
D1106_RS08235 (D1106_08265) 1764053..1764343 - 291 WP_005602215.1 DUF5389 family protein -
D1106_RS08240 (D1106_08270) 1764345..1765238 - 894 WP_005618012.1 site-specific tyrosine recombinase XerD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(22-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17192.19 Da        Isoelectric Point: 8.9312

>T110413 WP_005602211.1 NZ_CP031861:c1760792-1760325 [Actinobacillus pleuropneumoniae]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL

Download         Length: 468 bp

>T110413 NZ_CP031861:c1760792-1760325 [Actinobacillus pleuropneumoniae]
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGAAAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGTGCCTTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGTTCGGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAATCCGCAAGCAAAAC
AATTTTATTTAAAGTACGGTTTTTCATGTTCACCCATTGATGAGATGGTTTTAATGTTAAAACTCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9796.14 Da        Isoelectric Point: 4.4883

>AT110413 WP_005619269.1 NZ_CP031861:c1761056-1760796 [Actinobacillus pleuropneumoniae]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Download         Length: 261 bp

>AT110413 NZ_CP031861:c1761056-1760796 [Actinobacillus pleuropneumoniae]
ATGAGAACTGCGCCAATTAATTTACGAGCGATGCCTGATCAGCGTGATTTAATTGATTATGCGGCAAGCATTTTAGGTAA
AACACGTTCTGACTTTATGTTAGAAACCGCCTGCCAAGCTGCCCAAAATGTGATTTTAGATCGTACCGTTTTCCAATTAA
ATGAGCAGGCTTTCGAGCAATTTAACCGATTGCTAGAACAGCCAACAGCAGATAATCCGGGGTTAGATAAACTGTTAAAT
ACCAAAGCGGTGTGGGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A448U107

Antitoxin

Source ID Structure
AlphaFold DB A3N2I7

References