Detailed information of TA system TA110411

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 1463431..1463939
• Replicon: chromosome
• Accession: NZ_CP031861
• Organism: Actinobacillus pleuropneumoniae strain N 273

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0BQK9
• Locus tag: D1106_RS06705
• Protein ID: WP_005605064.1
• Coordinates: 1463679..1463939 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B0BQK8
• Locus tag: D1106_RS06700
• Protein ID: WP_005598318.1
• Coordinates: 1463431..1463682 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1106_RS06660 (D1106_06705)	1458967..1459515	-	549	WP_237593742.1	type IV pilus biogenesis/stability protein PilW	-
D1106_RS06665 (D1106_06710)	1459569..1460750	-	1182	WP_237593743.1	bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN	-
D1106_RS06690 (D1106_06735)	1461654..1463093	+	1440	WP_237592596.1	glutamate--tRNA ligase	-
D1106_RS06700 (D1106_06745)	1463431..1463682	+	252	WP_005598318.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
D1106_RS06705 (D1106_06750)	1463679..1463939	+	261	WP_005605064.1	Txe/YoeB family addiction module toxin	Toxin
D1106_RS06710 (D1106_06755)	1464098..1464265	-	168	WP_005598320.1	Trm112 family protein	-
D1106_RS06715 (D1106_06760)	1464267..1465247	-	981	WP_005608502.1	tetraacyldisaccharide 4'-kinase	-
D1106_RS06720 (D1106_06765)	1465341..1466600	-	1260	WP_237593744.1	ATP-dependent protease ATP-binding subunit ClpX	-
D1106_RS06725 (D1106_06770)	1466600..1467190	-	591	WP_005601821.1	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	-
D1106_RS06730 (D1106_06775)	1467314..1467706	+	393	WP_237593745.1	SufE family protein	-
D1106_RS06745 (D1106_06790)	1468065..1468838	-	774	WP_005598329.1	DNA polymerase III subunit epsilon	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10423.99 Da
• Isoelectric Point: 8.0109

>T110411 WP_005605064.1 NZ_CP031861:1463679-1463939 [Actinobacillus pleuropneumoniae]
MKLTFSSNAWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKLEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Nucleotide

• Length: 261 bp

>T110411 NZ_CP031861:1463679-1463939 [Actinobacillus pleuropneumoniae]
ATGAAGCTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACTGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9362.66 Da
• Isoelectric Point: 4.5659

>AT110411 WP_005598318.1 NZ_CP031861:1463431-1463682 [Actinobacillus pleuropneumoniae]
MQAITYTEARQNLAGTMSKVAEDFEPILITRSKGGNCVLMSYEQYCSLEETAYLMRSPTNAKRLLDSVAELRQGQGIERE
LIE

Nucleotide

• Length: 252 bp

>AT110411 NZ_CP031861:1463431-1463682 [Actinobacillus pleuropneumoniae]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATCTAGCCGGTACGATGTCAAAAGTAGCAGAAGATTTTGAGCCTAT
TTTAATTACAAGAAGCAAGGGCGGAAATTGCGTACTTATGTCGTATGAGCAGTATTGTTCACTTGAAGAAACCGCCTATT
TGATGCGTTCACCCACCAATGCAAAACGGCTATTGGATAGTGTGGCGGAATTAAGACAGGGACAAGGCATTGAAAGAGAG
CTAATCGAATGA

Structures

Toxin

• AlphaFold DB: B0BQK9

Antitoxin

• AlphaFold DB: B0BQK8