Detailed information of TA system TA110410

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-YefM
• Location: 2000876..2001591
• Replicon: chromosome
• Accession: NZ_CP031860
• Organism: Actinobacillus pleuropneumoniae strain 3906

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1107_RS09375
• Protein ID: WP_052293849.1
• Coordinates: 2000876..2001241 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B0BT01
• Locus tag: D1107_RS09380
• Protein ID: WP_005599447.1
• Coordinates: 2001304..2001591 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1107_RS09360 (D1107_09465)	1996461..1998167	-	1707	WP_237592765.1	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	-
D1107_RS09365 (D1107_09470)	1998263..1998544	-	282	WP_005599441.1	DNA-directed RNA polymerase subunit omega	-
D1107_RS09370 (D1107_09475)	1998671..2000752	-	2082	WP_237592766.1	ATP-dependent DNA helicase RecG	-
D1107_RS09375 (D1107_09480)	2000876..2001241	-	366	WP_052293849.1	type II toxin-antitoxin system VapC family toxin	Toxin
D1107_RS09380 (D1107_09485)	2001304..2001591	-	288	WP_005599447.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D1107_RS09385 (D1107_09490)	2001797..2003512	+	1716	WP_039709409.1	proline--tRNA ligase	-
D1107_RS09390 (D1107_09495)	2003578..2003766	-	189	WP_005602684.1	hypothetical protein	-
D1107_RS09395 (D1107_09500)	2003769..2004350	-	582	WP_005606496.1	sigma-70 family RNA polymerase sigma factor	-
D1107_RS09400 (D1107_09505)	2004439..2005395	+	957	WP_005619040.1	protein-methionine-sulfoxide reductase catalytic subunit MsrP	-
D1107_RS09405 (D1107_09510)	2005395..2005988	+	594	WP_237592767.1	protein-methionine-sulfoxide reductase heme-binding subunit MsrQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14014.06 Da
• Isoelectric Point: 8.4956

>T110410 WP_052293849.1 NZ_CP031860:c2001241-2000876 [Actinobacillus pleuropneumoniae]
IDTNVRQWLETIKPSQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHNVLSVYQAKSFSINNEIALLASEYHIPNK
MDLNDAYIAATAKYHNLVLVTRNLKDFNRCDIRLFNPFEPN

Nucleotide

• Length: 366 bp

>T110410 NZ_CP031860:c2001241-2000876 [Actinobacillus pleuropneumoniae]
ATAGATACCAATGTACGACAATGGTTAGAAACGATTAAACCGAGTCAGACGAATATTAGCTGTATCACGCTTTCCGAAAT
AAAAACGGGGATTTTACTTAAAGCTCGTAAAGATCCTATTCAAGCCGAGCGGTTAAATCATTGGTTTACCCATAATGTAT
TAAGCGTTTATCAAGCTAAATCCTTTTCTATAAATAATGAAATTGCGTTACTGGCTTCTGAATACCACATTCCAAATAAA
ATGGATTTAAACGATGCTTATATTGCCGCAACCGCTAAATATCATAATTTAGTGCTTGTTACTCGTAATTTGAAAGACTT
CAACCGTTGCGATATACGTTTATTTAATCCTTTCGAACCGAATTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11040.29 Da
• Isoelectric Point: 4.5578

>AT110410 WP_005599447.1 NZ_CP031860:c2001591-2001304 [Actinobacillus pleuropneumoniae]
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE

Nucleotide

• Length: 288 bp

>AT110410 NZ_CP031860:c2001591-2001304 [Actinobacillus pleuropneumoniae]
ATGCCAATTACTATTACCTCTCGAGAATTTAATCAACACGCCAGTAAAGTGCTGAAAATGGCAGAAAAAGAACCGGTTTT
TATCACTAAATGGGGAAAAATTGTCAGCGTTGTCTCCAATTATGTTGATTACAAACAGCACACAACGGTTGAGCCTAGCT
TTGAAGAACTATTTGCCTCATCTACGGATGAATCGGTTAGCGATGAGTTTTGGCAAGATTTTGAACAGACATTAACAAAA
ATTCGCAAAAGTAATAAATCCGAACAAATAGATTTTGGAGATGAATAA

Structures

Antitoxin

• AlphaFold DB: A3N3C5