Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1907019..1907647 Replicon chromosome
Accession NZ_CP031860
Organism Actinobacillus pleuropneumoniae strain 3906

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D1107_RS08805 Protein ID WP_005609156.1
Coordinates 1907249..1907647 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D1107_RS08800 Protein ID WP_039709385.1
Coordinates 1907019..1907249 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1107_RS08785 (D1107_08890) 1903648..1904857 + 1210 Protein_1690 IS3 family transposase -
D1107_RS08790 (D1107_08895) 1905253..1906608 + 1356 WP_237592744.1 antiviral reverse transcriptase Drt2 -
D1107_RS08795 1906771..1906911 - 141 WP_162835170.1 hypothetical protein -
D1107_RS08800 (D1107_08900) 1907019..1907249 + 231 WP_039709385.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D1107_RS08805 (D1107_08905) 1907249..1907647 + 399 WP_005609156.1 tRNA(fMet)-specific endonuclease VapC Toxin
D1107_RS08810 (D1107_08910) 1907782..1908198 - 417 WP_005618204.1 DUF417 family protein -
D1107_RS08815 (D1107_08915) 1908444..1909094 + 651 WP_237592745.1 DUF2202 domain-containing protein -
D1107_RS08820 (D1107_08920) 1909273..1910052 - 780 WP_115587743.1 hypothetical protein -
D1107_RS08825 (D1107_08925) 1910125..1911447 - 1323 WP_018652450.1 HslU--HslV peptidase ATPase subunit -
D1107_RS08830 (D1107_08930) 1911593..1912114 - 522 WP_005613306.1 ATP-dependent protease subunit HslV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1904597..1922442 17845


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(6-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15066.37 Da        Isoelectric Point: 7.3824

>T110409 WP_005609156.1 NZ_CP031860:1907249-1907647 [Actinobacillus pleuropneumoniae]
MLTYMLDTNIAIYVIKRRPIEVLDKFNLNSTRLCVSSITAAELYYGAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKCGKILGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLDNWV

Download         Length: 399 bp

>T110409 NZ_CP031860:1907249-1907647 [Actinobacillus pleuropneumoniae]
ATGCTAACTTATATGCTTGATACTAACATTGCGATTTATGTGATTAAACGCAGACCTATTGAAGTGCTGGATAAGTTTAA
TTTAAATTCTACTCGTCTTTGTGTAAGTAGTATCACTGCAGCGGAGTTGTATTATGGTGCAGAGAAAAGCCAGTTTCCGG
AACGAAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGCGGCTACTCACTTT
GGCAATATTAAAGCACATTTATCTAAGTGCGGTAAGATTCTCGGCGAGAACGATATTCATATTGCCGCGCATGCAAGAAG
TGAAGGACTCGTATTAGTAACCAATAACTTACGTGAATTTGAACGTGTAGAAGGATTGCGATTAGATAATTGGGTATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8581.65 Da        Isoelectric Point: 4.5203

>AT110409 WP_039709385.1 NZ_CP031860:1907019-1907249 [Actinobacillus pleuropneumoniae]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLGSATVSDDFMTEREISTQAEREDL

Download         Length: 231 bp

>AT110409 NZ_CP031860:1907019-1907249 [Actinobacillus pleuropneumoniae]
ATGGAAGCATCAGTATTTATGACAAATCGCAGTCAAGCGGTACGATTGCCGGCAGAAGTACGTTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTGGTAGGTAATGAACGTATTTTGGCACCGATTAACCAAAGTTGGGATAGCTTCTTTCTGGGGT
CGGCAACGGTAAGCGATGATTTCATGACAGAGCGTGAAATCAGCACTCAAGCCGAACGTGAGGATCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References