Detailed information of TA system TA110408

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1841030..1842687
• Replicon: chromosome
• Accession: NZ_CP031860
• Organism: Actinobacillus pleuropneumoniae strain 3906

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: D1107_RS08525
• Protein ID: WP_237592726.1
• Coordinates: 1841356..1842687 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A3N2X7
• Locus tag: D1107_RS08520
• Protein ID: WP_005613259.1
• Coordinates: 1841030..1841359 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1107_RS08495 (D1107_08595)	1837556..1838173	+	618	WP_005602440.1	dimethylsulfoxide reductase subunit B	-
D1107_RS08500 (D1107_08600)	1838175..1839008	+	834	WP_237592723.1	dimethyl sulfoxide reductase anchor subunit	-
D1107_RS08505 (D1107_08605)	1839064..1839669	+	606	WP_237592724.1	Tat proofreading chaperone DmsD	-
D1107_RS08510 (D1107_08610)	1839673..1840191	+	519	WP_237592725.1	ferredoxin-type protein NapF	-
D1107_RS08515 (D1107_08615)	1840188..1840817	-	630	WP_237585948.1	class I SAM-dependent methyltransferase	-
D1107_RS08520 (D1107_08620)	1841030..1841359	-	330	WP_005613259.1	helix-turn-helix domain-containing protein	Antitoxin
D1107_RS08525 (D1107_08625)	1841356..1842687	-	1332	WP_237592726.1	HipA domain-containing protein	Toxin
D1107_RS08530 (D1107_08630)	1843188..1844114	+	927	Protein_1639	Abi family protein	-
D1107_RS08535 (D1107_08635)	1844652..1846565	-	1914	WP_237592727.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (164-362)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-94)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51046.94 Da
• Isoelectric Point: 5.2253

>T110408 WP_237592726.1 NZ_CP031860:c1842687-1841356 [Actinobacillus pleuropneumoniae]
MSDISIKIKKLTLQTYVDNLWRDMAELYFNAQYELESMEYLTDYAVDFFGQANARSVSINYPVNVFIDHADKLMTALADI
IPAGASRRYWLEALDIKHLSISHQNYLLLKNGAISPIGNVRVKEAVPEIQSERYFPLNVVQNRQSDFLEYANQTGAIVGG
ATGAGGEAPKLLLKRQDKQIWIDNLQLGLDCDTAYLVKYPRGNYSELDCDILRAEYHYYHELRALGFSTIDTDLMKLEEG
ERYPSLWLPRFDMKFKDGKWERYAMESVYSMLQKYGGNLDHEQTIRNLLNVISASQFSNDFDNRHFVIEWVKRDLLNIAF
GNSDNHGRNTAFLRDDNHIWLSPIYDFAPMRADPEGIIRTTTWSKNGDTPQEFAGEYRFDKIADGLSDLIEPDILLRELR
MLATQLVGLKSRLTKRGVPKSILDFPSIGFDYLPEKLQRWGLV

Nucleotide

• Length: 1332 bp

>T110408 NZ_CP031860:c1842687-1841356 [Actinobacillus pleuropneumoniae]
ATGAGTGATATATCAATCAAAATTAAAAAATTAACATTGCAGACCTATGTTGATAATTTATGGCGAGATATGGCGGAGCT
TTATTTCAATGCTCAGTATGAATTAGAGAGCATGGAATATTTAACGGACTATGCCGTCGATTTTTTTGGGCAAGCGAATG
CCAGATCCGTATCAATTAATTATCCTGTAAATGTGTTTATTGATCATGCTGATAAGCTGATGACTGCACTTGCCGATATT
ATTCCTGCCGGAGCGAGTCGGCGTTATTGGCTGGAAGCTCTTGATATCAAGCACCTGTCGATTTCTCATCAAAATTACTT
ATTATTAAAAAATGGCGCAATATCCCCTATCGGCAATGTTCGAGTTAAAGAGGCTGTGCCAGAAATACAAAGTGAGCGTT
ATTTTCCATTAAATGTGGTACAAAACAGGCAGAGTGATTTTTTAGAATATGCAAATCAGACAGGAGCTATTGTAGGCGGA
GCGACCGGGGCTGGAGGAGAAGCACCAAAGCTATTACTTAAACGCCAAGATAAACAAATTTGGATTGATAATTTACAATT
AGGTCTAGATTGCGATACGGCTTATTTAGTGAAATATCCTCGTGGGAATTATTCAGAGTTGGACTGTGATATTTTAAGAG
CTGAATATCATTATTATCATGAACTGCGTGCATTAGGGTTTTCAACTATAGATACTGATCTAATGAAATTAGAAGAGGGG
GAACGTTATCCGTCTTTATGGCTACCTAGATTCGATATGAAGTTCAAAGATGGAAAATGGGAGCGATATGCTATGGAATC
GGTTTATTCTATGTTACAAAAATATGGTGGAAATCTTGATCATGAGCAGACTATTCGCAACTTACTCAATGTTATTTCAG
CTTCGCAATTTTCTAATGATTTTGATAACCGGCATTTTGTTATTGAATGGGTAAAGCGAGATTTGTTGAATATTGCTTTT
GGAAATAGTGATAATCATGGCAGAAATACCGCATTTTTACGTGATGATAATCATATTTGGCTATCCCCTATCTATGATTT
TGCTCCGATGCGGGCAGATCCGGAAGGTATTATCAGAACGACCACTTGGTCTAAAAATGGAGATACTCCTCAAGAATTTG
CCGGAGAATATCGCTTTGATAAAATAGCTGACGGTTTATCTGACCTTATTGAACCAGATATATTGTTAAGAGAATTAAGA
ATGCTTGCCACCCAATTAGTAGGTTTAAAATCTAGACTTACGAAGCGAGGTGTTCCGAAAAGCATTTTAGATTTTCCCTC
CATTGGTTTTGATTACTTACCTGAGAAGTTACAACGTTGGGGGCTGGTATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12320.45 Da
• Isoelectric Point: 10.8292

>AT110408 WP_005613259.1 NZ_CP031860:c1841359-1841030 [Actinobacillus pleuropneumoniae]
MTIQHKNASPTRSKVNGIERQLIRETIIVQLLKGEISQGQALRRLRVEALGINQQDYLKLAKVSRQTLSNIENDKGNYSI
ETINQVFKPMGLKLGLMPISKDLMASFLK

Nucleotide

• Length: 330 bp

>AT110408 NZ_CP031860:c1841359-1841030 [Actinobacillus pleuropneumoniae]
ATGACGATTCAACATAAAAATGCCTCACCGACACGCTCTAAAGTGAATGGCATTGAACGACAATTAATCCGTGAAACGAT
TATAGTACAGCTCTTAAAAGGTGAGATTAGCCAAGGGCAAGCACTGCGTCGATTAAGAGTGGAAGCATTGGGAATAAACC
AGCAGGATTATCTGAAATTAGCGAAAGTTTCTCGGCAGACACTTTCTAATATCGAAAATGATAAAGGAAACTATAGTATA
GAGACAATTAATCAGGTGTTTAAACCGATGGGACTAAAGCTAGGTCTTATGCCGATTTCAAAAGACTTGATGGCTTCCTT
TCTTAAATAA

Structures

Antitoxin

• AlphaFold DB: A3N2X7