Detailed information of TA system TA110406

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1474034..1474679
• Replicon: chromosome
• Accession: NZ_CP031860
• Organism: Actinobacillus pleuropneumoniae strain 3906

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: B0BQU7
• Locus tag: D1107_RS06695
• Protein ID: WP_005619674.1
• Coordinates: 1474308..1474679 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: D1107_RS06690
• Protein ID: WP_005598477.1
• Coordinates: 1474034..1474327 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1107_RS06660 (D1107_06735)	1469366..1470049	-	684	WP_005605188.1	arginine ABC transporter permease ArtM	-
D1107_RS06665 (D1107_06740)	1470049..1470720	-	672	WP_237592627.1	arginine ABC transporter permease ArtQ	-
D1107_RS06670 (D1107_06745)	1470726..1471445	-	720	WP_043995135.1	transporter substrate-binding domain-containing protein	-
D1107_RS06675 (D1107_06750)	1471465..1472199	-	735	WP_005598473.1	arginine ABC transporter ATP-binding protein ArtP	-
D1107_RS06680 (D1107_06755)	1472424..1472921	-	498	WP_005615760.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
D1107_RS06685 (D1107_06760)	1472994..1473956	+	963	WP_005619672.1	calcium/sodium antiporter	-
D1107_RS06690 (D1107_06765)	1474034..1474327	-	294	WP_005598477.1	helix-turn-helix domain-containing protein	Antitoxin
D1107_RS06695 (D1107_06770)	1474308..1474679	-	372	WP_005619674.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1107_RS06700 (D1107_06775)	1474873..1476624	+	1752	WP_237592628.1	protein-disulfide reductase DsbD	-
D1107_RS06705 (D1107_06780)	1476682..1477251	+	570	WP_005601959.1	elongation factor P hydroxylase	-
D1107_RS06710 (D1107_06785)	1477295..1478149	-	855	WP_005615766.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (32-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 15066.57 Da
• Isoelectric Point: 10.4054

>T110406 WP_005619674.1 NZ_CP031860:c1474679-1474308 [Actinobacillus pleuropneumoniae]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Nucleotide

• Length: 372 bp

>T110406 NZ_CP031860:c1474679-1474308 [Actinobacillus pleuropneumoniae]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTACTAAAAGAACG
GCAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGTCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10935.81 Da
• Isoelectric Point: 10.3120

>AT110406 WP_005598477.1 NZ_CP031860:c1474327-1474034 [Actinobacillus pleuropneumoniae]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Nucleotide

• Length: 294 bp

>AT110406 NZ_CP031860:c1474327-1474034 [Actinobacillus pleuropneumoniae]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTCGGAAATAGCGGAAACTCAGTTTCG
CATACGACTTATTTTAGAAATCATTGAAACCCGTCAGCAGCTCGGTATTTCTCAACGAAAATTGGAGAAATTAAGCGGTG
TAAAACAATCTATGATTGCTCGGGTAGAAAAAGGCTCGGTTAATCCGTCGTTGGCGACGGTATTAAAGTTGCTTGTGCCG
TTGGGGAAAACTTTACAAATCGTACCGTTAGATAAAAACAAAACGGTACGTTAA

Structures

Toxin

• AlphaFold DB: A3N206