Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1388240..1388748 Replicon chromosome
Accession NZ_CP031860
Organism Actinobacillus pleuropneumoniae strain 3906

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D1107_RS06245 Protein ID WP_237592597.1
Coordinates 1388488..1388748 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D1107_RS06240 Protein ID WP_017357689.1
Coordinates 1388240..1388491 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1107_RS06200 (D1107_06270) 1383775..1384323 - 549 WP_237592595.1 type IV pilus biogenesis/stability protein PilW -
D1107_RS06205 (D1107_06275) 1384377..1385558 - 1182 WP_005608495.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
D1107_RS06230 (D1107_06300) 1386463..1387902 + 1440 WP_237592596.1 glutamate--tRNA ligase -
D1107_RS06240 (D1107_06310) 1388240..1388491 + 252 WP_017357689.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
D1107_RS06245 (D1107_06315) 1388488..1388748 + 261 WP_237592597.1 Txe/YoeB family addiction module toxin Toxin
D1107_RS06250 (D1107_06320) 1388907..1389074 - 168 WP_005605066.1 Trm112 family protein -
D1107_RS06255 (D1107_06325) 1389076..1390056 - 981 WP_237592598.1 tetraacyldisaccharide 4'-kinase -
D1107_RS06260 (D1107_06330) 1390150..1391409 - 1260 WP_005598324.1 ATP-dependent protease ATP-binding subunit ClpX -
D1107_RS06265 (D1107_06335) 1391409..1391999 - 591 Protein_1221 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
D1107_RS06270 (D1107_06340) 1392121..1392513 + 393 WP_237592599.1 SufE family protein -
D1107_RS06285 (D1107_06355) 1392872..1393645 - 774 WP_043995130.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(1-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10405.97 Da        Isoelectric Point: 8.0109

>T110405 WP_237592597.1 NZ_CP031860:1388488-1388748 [Actinobacillus pleuropneumoniae]
MKLTFSSNSWEDYLYWQKTDKIILKRINSLIKDIQRQPLEGIGKLEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Download         Length: 261 bp

>T110405 NZ_CP031860:1388488-1388748 [Actinobacillus pleuropneumoniae]
ATGAAGCTAACTTTCTCGTCTAATTCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCACTCGAAGGCATAGGAAAACTGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9336.62 Da        Isoelectric Point: 4.5659

>AT110405 WP_017357689.1 NZ_CP031860:1388240-1388491 [Actinobacillus pleuropneumoniae]
MQAITYTEARQNLAGTMSKVTEDFEPVLITRSKGGNCVLMSYEQYSSLEETAYLMRSPANAQRLLDSMAELKQGKGIERE
LIE

Download         Length: 252 bp

>AT110405 NZ_CP031860:1388240-1388491 [Actinobacillus pleuropneumoniae]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATTTAGCAGGTACAATGTCAAAAGTAACAGAAGATTTTGAACCTGT
TTTAATTACAAGAAGCAAGGGTGGAAATTGCGTACTTATGTCGTATGAGCAGTATAGTTCACTTGAAGAAACCGCCTATT
TAATGCGTTCCCCGGCTAACGCTCAAAGATTACTAGACAGCATGGCAGAATTGAAGCAAGGGAAAGGCATTGAAAGAGAG
CTAATCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References