Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-YefM
Location 1418224..1418732 Replicon chromosome
Accession NZ_CP031859
Organism Actinobacillus pleuropneumoniae strain HS143

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag D1108_RS06365 Protein ID WP_237593298.1
Coordinates 1418472..1418732 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag D1108_RS06360 Protein ID WP_017357689.1
Coordinates 1418224..1418475 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1108_RS06320 (D1108_06365) 1413759..1414307 - 549 WP_237593297.1 type IV pilus biogenesis/stability protein PilW -
D1108_RS06325 (D1108_06370) 1414361..1415542 - 1182 WP_005608495.1 bifunctional tRNA (adenosine(37)-C2)-methyltransferase TrmG/ribosomal RNA large subunit methyltransferase RlmN -
D1108_RS06350 (D1108_06395) 1416447..1417886 + 1440 WP_237592596.1 glutamate--tRNA ligase -
D1108_RS06360 (D1108_06405) 1418224..1418475 + 252 WP_017357689.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
D1108_RS06365 (D1108_06410) 1418472..1418732 + 261 WP_237593298.1 Txe/YoeB family addiction module toxin Toxin
D1108_RS06370 (D1108_06415) 1418891..1419058 - 168 WP_005598320.1 Trm112 family protein -
D1108_RS06375 (D1108_06420) 1419060..1420040 - 981 WP_237593299.1 tetraacyldisaccharide 4'-kinase -
D1108_RS06380 (D1108_06425) 1420134..1421393 - 1260 WP_005598324.1 ATP-dependent protease ATP-binding subunit ClpX -
D1108_RS06385 (D1108_06430) 1421393..1421983 - 591 WP_005598326.1 ATP-dependent Clp endopeptidase proteolytic subunit ClpP -
D1108_RS06390 (D1108_06435) 1422105..1422497 + 393 WP_005620423.1 SufE family protein -
D1108_RS06405 (D1108_06450) 1422856..1423629 - 774 WP_237593300.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10439.99 Da        Isoelectric Point: 8.0109

>T110400 WP_237593298.1 NZ_CP031859:1418472-1418732 [Actinobacillus pleuropneumoniae]
MKLTFSSNSWEDYLYWQKTDKIILKRINSLIKDIQRQPFEGIGKLEPLKFNLSGFWSRRINEEHRLIYSVEDEAILIVAC
RYHYDQ

Download         Length: 261 bp

>T110400 NZ_CP031859:1418472-1418732 [Actinobacillus pleuropneumoniae]
ATGAAGCTAACTTTCTCGTCTAATTCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACTGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9336.62 Da        Isoelectric Point: 4.5659

>AT110400 WP_017357689.1 NZ_CP031859:1418224-1418475 [Actinobacillus pleuropneumoniae]
MQAITYTEARQNLAGTMSKVTEDFEPVLITRSKGGNCVLMSYEQYSSLEETAYLMRSPANAQRLLDSMAELKQGKGIERE
LIE

Download         Length: 252 bp

>AT110400 NZ_CP031859:1418224-1418475 [Actinobacillus pleuropneumoniae]
ATGCAAGCAATAACCTACACAGAAGCACGCCAAAATTTAGCAGGTACAATGTCAAAAGTAACAGAAGATTTTGAACCTGT
TTTAATTACAAGAAGCAAGGGTGGAAATTGCGTACTTATGTCGTATGAGCAGTATAGTTCACTTGAAGAAACCGCCTATT
TAATGCGTTCCCCGGCTAACGCTCAAAGATTACTAGACAGCATGGCAGAATTGAAGCAAGGGAAAGGCATTGAAAGAGAG
CTAATCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References