Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1193628..1194359 Replicon chromosome
Accession NZ_CP031858
Organism Actinobacillus pleuropneumoniae strain A-85/14

Toxin (Protein)


Gene name tacT Uniprot ID A0A448U107
Locus tag D1109_RS05685 Protein ID WP_005602211.1
Coordinates 1193628..1194095 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID B0BRD3
Locus tag D1109_RS05690 Protein ID WP_005619269.1
Coordinates 1194099..1194359 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1109_RS05660 (D1109_05665) 1188987..1189358 - 372 WP_005598830.1 CrcB family protein -
D1109_RS05665 (D1109_05670) 1189361..1190425 - 1065 WP_011848610.1 MFS transporter -
D1109_RS05670 (D1109_05675) 1190520..1191629 + 1110 WP_012263272.1 anhydro-N-acetylmuramic acid kinase -
D1109_RS05675 (D1109_05680) 1191683..1192597 + 915 WP_237610872.1 N-acetylmuramic acid 6-phosphate etherase -
D1109_RS05680 (D1109_05685) 1192664..1193545 - 882 WP_237610873.1 50S ribosomal protein L11 methyltransferase -
D1109_RS05685 (D1109_05690) 1193628..1194095 - 468 WP_005602211.1 GNAT family N-acetyltransferase Toxin
D1109_RS05690 (D1109_05695) 1194099..1194359 - 261 WP_005619269.1 DUF1778 domain-containing protein Antitoxin
D1109_RS05695 (D1109_05700) 1194480..1195940 - 1461 WP_237593341.1 metalloprotease TldD -
D1109_RS05700 (D1109_05705) 1196070..1197329 + 1260 WP_237610874.1 tRNA lysidine(34) synthetase TilS -
D1109_RS05705 (D1109_05710) 1197356..1197568 - 213 WP_237593654.1 DUF5389 family protein -
D1109_RS05710 (D1109_05715) 1197648..1198541 - 894 WP_005598850.1 site-specific tyrosine recombinase XerD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(22-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17192.19 Da        Isoelectric Point: 8.9312

>T110396 WP_005602211.1 NZ_CP031858:c1194095-1193628 [Actinobacillus pleuropneumoniae]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL

Download         Length: 468 bp

>T110396 NZ_CP031858:c1194095-1193628 [Actinobacillus pleuropneumoniae]
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGAAAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGTGCCTTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGTTCGGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAATCCGCAAGCAAAAC
AATTTTATTTAAAGTACGGTTTTTCATGTTCACCCATTGATGAGATGGTTTTAATGTTAAAACTCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9796.14 Da        Isoelectric Point: 4.4883

>AT110396 WP_005619269.1 NZ_CP031858:c1194359-1194099 [Actinobacillus pleuropneumoniae]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Download         Length: 261 bp

>AT110396 NZ_CP031858:c1194359-1194099 [Actinobacillus pleuropneumoniae]
ATGAGAACTGCGCCAATTAATTTACGAGCGATGCCTGATCAGCGTGATTTAATTGATTATGCGGCAAGCATTTTAGGTAA
AACACGTTCTGACTTTATGTTAGAAACCGCCTGCCAAGCTGCCCAAAATGTGATTTTAGATCGTACCGTTTTCCAATTAA
ATGAGCAGGCTTTCGAGCAATTTAACCGATTGCTAGAACAGCCAACAGCAGATAATCCGGGGTTAGATAAACTGTTAAAT
ACCAAAGCGGTGTGGGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A448U107

Antitoxin

Source ID Structure
AlphaFold DB A3N2I7

References