Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 144105..144755 Replicon chromosome
Accession NZ_CP031858
Organism Actinobacillus pleuropneumoniae strain A-85/14

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D1109_RS00640 Protein ID WP_215577551.1
Coordinates 144105..144494 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D1109_RS00645 Protein ID WP_215577552.1
Coordinates 144495..144755 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1109_RS00625 (D1109_00605) 139903..140943 + 1041 WP_005603118.1 IS481 family transposase -
D1109_RS00630 (D1109_00610) 141052..142338 - 1287 WP_237611191.1 Xaa-Pro aminopeptidase -
D1109_RS00635 (D1109_00615) 142747..143970 - 1224 WP_237611192.1 ATP-binding protein -
D1109_RS00640 (D1109_00620) 144105..144494 - 390 WP_215577551.1 type II toxin-antitoxin system VapC family toxin Toxin
D1109_RS00645 (D1109_00625) 144495..144755 - 261 WP_215577552.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D1109_RS00650 (D1109_00630) 144889..146910 - 2022 WP_005617154.1 excinuclease ABC subunit UvrB -
D1109_RS00655 (D1109_00640) 147087..147899 + 813 WP_005604121.1 iron uptake system protein EfeO -
D1109_RS00660 (D1109_00645) 147911..149104 + 1194 WP_237611193.1 iron uptake transporter deferrochelatase/peroxidase subunit -
D1109_RS00665 (D1109_00650) 149115..149735 + 621 WP_005596976.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 139903..140943 1040


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14793.16 Da        Isoelectric Point: 5.8397

>T110393 WP_215577551.1 NZ_CP031858:c144494-144105 [Actinobacillus pleuropneumoniae]
MYMLDTNTVSYFFRQEPTVVKKLQQLNPELICISSVTAAELFYGVKKRNNQKLTAFLNTFLSAITVMDWDYQVAEVYGQL
RAEMERGGKIMGVQDQMIGAHALATECILVSSDKAFQFIPNLVLENWWK

Download         Length: 390 bp

>T110393 NZ_CP031858:c144494-144105 [Actinobacillus pleuropneumoniae]
ATGTATATGCTAGATACTAATACGGTGAGTTATTTCTTTAGGCAAGAGCCTACTGTGGTTAAGAAACTACAACAACTTAA
TCCGGAATTGATTTGTATTTCATCGGTCACGGCTGCAGAGTTGTTTTATGGTGTAAAAAAACGTAATAATCAGAAACTTA
CTGCATTTTTAAATACTTTTTTATCCGCAATTACGGTTATGGATTGGGATTATCAAGTGGCGGAAGTTTATGGTCAGCTG
CGAGCAGAGATGGAACGAGGAGGCAAAATCATGGGTGTTCAAGATCAAATGATTGGAGCTCATGCCCTAGCAACAGAATG
TATTCTTGTTTCCAGCGATAAAGCCTTTCAATTTATCCCTAATCTCGTATTAGAAAATTGGTGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10289.67 Da        Isoelectric Point: 6.3511

>AT110393 WP_215577552.1 NZ_CP031858:c144755-144495 [Actinobacillus pleuropneumoniae]
MEKVARLFRNGRNQAVRLPVEFEFNAKQVYVFKEANGDITLSTRSRNQQNWQKVFELLPMLECDEQFLSEKERKQEMATR
DPFEGF

Download         Length: 261 bp

>AT110393 NZ_CP031858:c144755-144495 [Actinobacillus pleuropneumoniae]
ATGGAAAAGGTCGCACGTTTATTTAGAAACGGACGTAATCAAGCCGTACGATTACCGGTTGAATTTGAGTTTAATGCGAA
GCAAGTTTATGTGTTTAAAGAAGCAAACGGCGATATTACGCTTTCGACACGTTCTCGCAATCAGCAAAATTGGCAGAAAG
TCTTTGAGTTATTACCAATGCTTGAATGTGATGAACAGTTTTTATCGGAAAAAGAACGCAAGCAAGAAATGGCAACTCGT
GATCCCTTTGAGGGCTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References