Detailed information of TA system TA110392

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-YefM
• Location: 2068212..2068927
• Replicon: chromosome
• Accession: NZ_CP031856
• Organism: Actinobacillus pleuropneumoniae strain 16287-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1110_RS09810
• Protein ID: WP_237586349.1
• Coordinates: 2068212..2068577 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B0BT01
• Locus tag: D1110_RS09815
• Protein ID: WP_005599447.1
• Coordinates: 2068640..2068927 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1110_RS09795 (D1110_09885)	2063797..2065503	-	1707	WP_005609259.1	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	-
D1110_RS09800 (D1110_09890)	2065599..2065880	-	282	WP_005599441.1	DNA-directed RNA polymerase subunit omega	-
D1110_RS09805 (D1110_09895)	2066007..2068088	-	2082	WP_237585971.1	ATP-dependent DNA helicase RecG	-
D1110_RS09810 (D1110_09900)	2068212..2068577	-	366	WP_237586349.1	type II toxin-antitoxin system VapC family toxin	Toxin
D1110_RS09815 (D1110_09905)	2068640..2068927	-	288	WP_005599447.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D1110_RS09820 (D1110_09910)	2069133..2070848	+	1716	WP_237585972.1	proline--tRNA ligase	-
D1110_RS09825 (D1110_09915)	2070914..2071102	-	189	WP_005602684.1	hypothetical protein	-
D1110_RS09830 (D1110_09920)	2071105..2071686	-	582	WP_005599450.1	sigma-70 family RNA polymerase sigma factor	-
D1110_RS09835 (D1110_09925)	2071775..2072731	+	957	WP_005619040.1	protein-methionine-sulfoxide reductase catalytic subunit MsrP	-
D1110_RS09840 (D1110_09930)	2072731..2073324	+	594	WP_005599453.1	protein-methionine-sulfoxide reductase heme-binding subunit MsrQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-103)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 13894.93 Da
• Isoelectric Point: 8.2783

>T110392 WP_237586349.1 NZ_CP031856:c2068577-2068212 [Actinobacillus pleuropneumoniae]
MDTNVRQWLATIKPSQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHNVLSVYQAKSFSINNEIASLASEYHIPNK
MDLNDAYIAATAKYHNLVLVTRNLKDFNCCDIRLFNPFEPN

Nucleotide

• Length: 366 bp

>T110392 NZ_CP031856:c2068577-2068212 [Actinobacillus pleuropneumoniae]
ATGGATACCAATGTACGACAATGGTTAGCAACGATTAAACCGAGTCAGACGAATATTAGCTGTATCACGCTTTCCGAAAT
AAAAACGGGGATTTTACTCAAAGCTCGTAAAGATCCTATTCAAGCCGAGCGGTTAAATCATTGGTTTACCCATAATGTAT
TAAGCGTTTATCAAGCTAAATCCTTTTCTATAAATAATGAAATTGCGTCACTGGCTTCTGAATACCACATTCCAAATAAA
ATGGATTTAAACGATGCTTATATTGCCGCAACCGCTAAATATCATAATTTAGTGCTTGTTACTCGTAATTTGAAAGACTT
CAACTGTTGCGATATACGTTTATTTAATCCTTTCGAACCGAATTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11040.29 Da
• Isoelectric Point: 4.5578

>AT110392 WP_005599447.1 NZ_CP031856:c2068927-2068640 [Actinobacillus pleuropneumoniae]
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE

Nucleotide

• Length: 288 bp

>AT110392 NZ_CP031856:c2068927-2068640 [Actinobacillus pleuropneumoniae]
ATGCCAATTACTATTACCTCTCGAGAATTTAATCAACACGCCAGTAAAGTGCTGAAAATGGCAGAAAAAGAACCGGTTTT
TATCACTAAATGGGGAAAAATTGTCAGCGTTGTCTCCAATTATGTTGATTACAAACAGCACACAACGGTTGAGCCTAGCT
TTGAAGAACTATTTGCCTCATCTACGGATGAATCGGTTAGCGATGAGTTTTGGCAAGATTTTGAACAGACATTAACAAAA
ATTCGCAAAAGTAATAAATCCGAACAAATAGATTTTGGAGATGAATAA

Structures

Antitoxin

• AlphaFold DB: A3N3C5