Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1758647..1759378 Replicon chromosome
Accession NZ_CP031856
Organism Actinobacillus pleuropneumoniae strain 16287-1

Toxin (Protein)


Gene name tacT Uniprot ID A0A448U107
Locus tag D1110_RS08180 Protein ID WP_005602211.1
Coordinates 1758647..1759114 (-) Length 156 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID B0BRD3
Locus tag D1110_RS08185 Protein ID WP_005619269.1
Coordinates 1759118..1759378 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1110_RS08155 (D1110_08215) 1754006..1754377 - 372 WP_005598830.1 CrcB family protein -
D1110_RS08160 (D1110_08220) 1754380..1755444 - 1065 WP_005602204.1 MFS transporter -
D1110_RS08165 (D1110_08225) 1755539..1756648 + 1110 WP_005608870.1 anhydro-N-acetylmuramic acid kinase -
D1110_RS08170 (D1110_08230) 1756701..1757615 + 915 WP_005598836.1 N-acetylmuramic acid 6-phosphate etherase -
D1110_RS08175 (D1110_08235) 1757682..1758563 - 882 WP_043995145.1 50S ribosomal protein L11 methyltransferase -
D1110_RS08180 (D1110_08240) 1758647..1759114 - 468 WP_005602211.1 GNAT family N-acetyltransferase Toxin
D1110_RS08185 (D1110_08245) 1759118..1759378 - 261 WP_005619269.1 DUF1778 domain-containing protein Antitoxin
D1110_RS08190 (D1110_08250) 1759499..1760959 - 1461 WP_005608884.1 metalloprotease TldD -
D1110_RS08195 (D1110_08255) 1761089..1762348 + 1260 WP_005615928.1 tRNA lysidine(34) synthetase TilS -
D1110_RS08200 (D1110_08260) 1762375..1762665 - 291 WP_005602215.1 DUF5389 family protein -
D1110_RS08205 (D1110_08265) 1762667..1763560 - 894 WP_005598850.1 site-specific tyrosine recombinase XerD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(22-142)

Antitoxin

Vibrio phage ICP1, Orf50

(6-80)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17192.19 Da        Isoelectric Point: 8.9312

>T110390 WP_005602211.1 NZ_CP031856:c1759114-1758647 [Actinobacillus pleuropneumoniae]
MHAPELLSEQHIVRYFQCGEVVLDQWLQRTALKNQQNNASKTFVVCDENKQVMGFYCLSAGSVSHQFVAGALRRNMPDPI
PVIILGRLAVDCSAQGKQLGVSMLKDAVLKSKTVANQIGVKALLVHALNPQAKQFYLKYGFSCSPIDEMVLMLKL

Download         Length: 468 bp

>T110390 NZ_CP031856:c1759114-1758647 [Actinobacillus pleuropneumoniae]
ATGCACGCACCGGAACTGCTTTCCGAGCAACATATTGTGCGATATTTTCAATGTGGTGAGGTCGTGCTAGACCAATGGCT
ACAACGTACTGCATTGAAAAATCAGCAAAATAATGCCAGTAAAACCTTTGTTGTGTGTGATGAAAATAAACAGGTGATGG
GATTTTATTGTTTATCTGCCGGTTCGGTGAGCCATCAGTTTGTTGCAGGTGCCTTAAGACGTAATATGCCCGATCCGATT
CCCGTGATTATTTTAGGTAGATTAGCGGTCGATTGTTCGGCACAGGGTAAGCAGTTAGGCGTATCAATGTTAAAAGATGC
GGTCTTAAAATCGAAGACGGTGGCGAACCAAATCGGGGTAAAAGCATTGCTTGTTCATGCGTTAAATCCGCAAGCAAAAC
AATTTTATTTAAAGTACGGTTTTTCATGTTCACCCATTGATGAGATGGTTTTAATGTTAAAACTCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9796.14 Da        Isoelectric Point: 4.4883

>AT110390 WP_005619269.1 NZ_CP031856:c1759378-1759118 [Actinobacillus pleuropneumoniae]
MRTAPINLRAMPDQRDLIDYAASILGKTRSDFMLETACQAAQNVILDRTVFQLNEQAFEQFNRLLEQPTADNPGLDKLLN
TKAVWE

Download         Length: 261 bp

>AT110390 NZ_CP031856:c1759378-1759118 [Actinobacillus pleuropneumoniae]
ATGAGAACTGCGCCAATTAATTTACGAGCGATGCCTGATCAGCGTGATTTAATTGATTATGCGGCAAGCATTTTAGGTAA
AACACGTTCTGACTTTATGTTAGAAACCGCCTGCCAAGCTGCCCAAAATGTGATTTTAGATCGTACCGTTTTCCAATTAA
ATGAGCAGGCTTTCGAGCAATTTAACCGATTGCTAGAACAGCCAACAGCAGATAATCCGGGGTTAGATAAACTGTTAAAT
ACCAAAGCGGTGTGGGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A448U107

Antitoxin

Source ID Structure
AlphaFold DB A3N2I7

References