Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 766069..766719 Replicon chromosome
Accession NZ_CP031856
Organism Actinobacillus pleuropneumoniae strain 16287-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D1110_RS03555 Protein ID WP_215577551.1
Coordinates 766069..766458 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D1110_RS03560 Protein ID WP_215577552.1
Coordinates 766459..766719 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1110_RS03540 (D1110_03535) 761760..762956 + 1197 WP_005611904.1 amino acid aminotransferase -
D1110_RS03545 (D1110_03540) 763015..764301 - 1287 WP_237586237.1 Xaa-Pro aminopeptidase -
D1110_RS03550 (D1110_03545) 764710..765933 - 1224 WP_237586238.1 ATP-binding protein -
D1110_RS03555 (D1110_03550) 766069..766458 - 390 WP_215577551.1 type II toxin-antitoxin system VapC family toxin Toxin
D1110_RS03560 (D1110_03555) 766459..766719 - 261 WP_215577552.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D1110_RS03565 (D1110_03560) 766853..768874 - 2022 WP_237586239.1 excinuclease ABC subunit UvrB -
D1110_RS03570 (D1110_03570) 769051..769863 + 813 WP_117374109.1 iron uptake system protein EfeO -
D1110_RS03575 (D1110_03575) 769875..771068 + 1194 WP_205470243.1 iron uptake transporter deferrochelatase/peroxidase subunit -
D1110_RS03580 (D1110_03580) 771079..771699 + 621 WP_005607537.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14793.16 Da        Isoelectric Point: 5.8397

>T110387 WP_215577551.1 NZ_CP031856:c766458-766069 [Actinobacillus pleuropneumoniae]
MYMLDTNTVSYFFRQEPTVVKKLQQLNPELICISSVTAAELFYGVKKRNNQKLTAFLNTFLSAITVMDWDYQVAEVYGQL
RAEMERGGKIMGVQDQMIGAHALATECILVSSDKAFQFIPNLVLENWWK

Download         Length: 390 bp

>T110387 NZ_CP031856:c766458-766069 [Actinobacillus pleuropneumoniae]
ATGTATATGCTAGATACTAATACGGTGAGTTATTTCTTTAGGCAAGAGCCTACTGTGGTTAAGAAACTACAACAACTTAA
TCCGGAATTGATTTGTATTTCATCGGTCACGGCTGCAGAGTTGTTTTATGGTGTAAAAAAACGTAATAATCAGAAACTTA
CTGCATTTTTAAATACTTTTTTATCCGCAATTACGGTTATGGATTGGGATTATCAAGTGGCGGAAGTTTATGGTCAGCTG
CGAGCAGAGATGGAACGAGGAGGCAAAATCATGGGTGTTCAAGATCAAATGATTGGAGCTCATGCCCTAGCAACAGAATG
TATTCTTGTTTCCAGCGATAAAGCCTTTCAATTTATCCCTAATCTCGTATTAGAAAATTGGTGGAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10289.67 Da        Isoelectric Point: 6.3511

>AT110387 WP_215577552.1 NZ_CP031856:c766719-766459 [Actinobacillus pleuropneumoniae]
MEKVARLFRNGRNQAVRLPVEFEFNAKQVYVFKEANGDITLSTRSRNQQNWQKVFELLPMLECDEQFLSEKERKQEMATR
DPFEGF

Download         Length: 261 bp

>AT110387 NZ_CP031856:c766719-766459 [Actinobacillus pleuropneumoniae]
ATGGAAAAGGTCGCACGTTTATTTAGAAACGGACGTAATCAAGCCGTACGATTACCGGTTGAATTTGAGTTTAATGCGAA
GCAAGTTTATGTGTTTAAAGAAGCAAACGGCGATATTACGCTTTCGACACGTTCTCGCAATCAGCAAAATTGGCAGAAAG
TCTTTGAGTTATTACCAATGCTTGAATGTGATGAACAGTTTTTATCGGAAAAAGAACGCAAGCAAGAAATGGCAACTCGT
GATCCCTTTGAGGGCTTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References