Detailed information of TA system TA110387

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-MazE
• Location: 766069..766719
• Replicon: chromosome
• Accession: NZ_CP031856
• Organism: Actinobacillus pleuropneumoniae strain 16287-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1110_RS03555
• Protein ID: WP_215577551.1
• Coordinates: 766069..766458 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: D1110_RS03560
• Protein ID: WP_215577552.1
• Coordinates: 766459..766719 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-117)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14793.16 Da
• Isoelectric Point: 5.8397

>T110387 WP_215577551.1 NZ_CP031856:c766458-766069 [Actinobacillus pleuropneumoniae]
MYMLDTNTVSYFFRQEPTVVKKLQQLNPELICISSVTAAELFYGVKKRNNQKLTAFLNTFLSAITVMDWDYQVAEVYGQL
RAEMERGGKIMGVQDQMIGAHALATECILVSSDKAFQFIPNLVLENWWK

Nucleotide

• Length: 390 bp

>T110387 NZ_CP031856:c766458-766069 [Actinobacillus pleuropneumoniae]
ATGTATATGCTAGATACTAATACGGTGAGTTATTTCTTTAGGCAAGAGCCTACTGTGGTTAAGAAACTACAACAACTTAA
TCCGGAATTGATTTGTATTTCATCGGTCACGGCTGCAGAGTTGTTTTATGGTGTAAAAAAACGTAATAATCAGAAACTTA
CTGCATTTTTAAATACTTTTTTATCCGCAATTACGGTTATGGATTGGGATTATCAAGTGGCGGAAGTTTATGGTCAGCTG
CGAGCAGAGATGGAACGAGGAGGCAAAATCATGGGTGTTCAAGATCAAATGATTGGAGCTCATGCCCTAGCAACAGAATG
TATTCTTGTTTCCAGCGATAAAGCCTTTCAATTTATCCCTAATCTCGTATTAGAAAATTGGTGGAAGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10289.67 Da
• Isoelectric Point: 6.3511

>AT110387 WP_215577552.1 NZ_CP031856:c766719-766459 [Actinobacillus pleuropneumoniae]
MEKVARLFRNGRNQAVRLPVEFEFNAKQVYVFKEANGDITLSTRSRNQQNWQKVFELLPMLECDEQFLSEKERKQEMATR
DPFEGF

Nucleotide

• Length: 261 bp

>AT110387 NZ_CP031856:c766719-766459 [Actinobacillus pleuropneumoniae]
ATGGAAAAGGTCGCACGTTTATTTAGAAACGGACGTAATCAAGCCGTACGATTACCGGTTGAATTTGAGTTTAATGCGAA
GCAAGTTTATGTGTTTAAAGAAGCAAACGGCGATATTACGCTTTCGACACGTTCTCGCAATCAGCAAAATTGGCAGAAAG
TCTTTGAGTTATTACCAATGCTTGAATGTGATGAACAGTTTTTATCGGAAAAAGAACGCAAGCAAGAAATGGCAACTCGT
GATCCCTTTGAGGGCTTTTAG