Detailed information of TA system TA110386

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-YefM
• Location: 1990615..1991330
• Replicon: chromosome
• Accession: NZ_CP031855
• Organism: Actinobacillus pleuropneumoniae strain 7311555

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: D1111_RS09340
• Protein ID: WP_237610688.1
• Coordinates: 1990615..1990980 (-)
• Length: 122 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: B0BT01
• Locus tag: D1111_RS09345
• Protein ID: WP_005599447.1
• Coordinates: 1991043..1991330 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1111_RS09325 (D1111_09395)	1986200..1987906	-	1707	WP_237610355.1	bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase	-
D1111_RS09330 (D1111_09400)	1988002..1988283	-	282	WP_237610356.1	DNA-directed RNA polymerase subunit omega	-
D1111_RS09335 (D1111_09405)	1988410..1990491	-	2082	WP_237610357.1	ATP-dependent DNA helicase RecG	-
D1111_RS09340 (D1111_09410)	1990615..1990980	-	366	WP_237610688.1	type II toxin-antitoxin system VapC family toxin	Toxin
D1111_RS09345 (D1111_09415)	1991043..1991330	-	288	WP_005599447.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
D1111_RS09350 (D1111_09420)	1991536..1993251	+	1716	WP_215578121.1	proline--tRNA ligase	-
D1111_RS09355 (D1111_09425)	1993317..1993505	-	189	WP_005602684.1	hypothetical protein	-
D1111_RS09360 (D1111_09430)	1993508..1994089	-	582	WP_237610358.1	sigma-70 family RNA polymerase sigma factor	-
D1111_RS09365 (D1111_09435)	1994178..1995134	+	957	WP_005619040.1	protein-methionine-sulfoxide reductase catalytic subunit MsrP	-
D1111_RS09370 (D1111_09440)	1995134..1995727	+	594	WP_005599453.1	protein-methionine-sulfoxide reductase heme-binding subunit MsrQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-109)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 122 a.a.
• Molecular weight: 14000.08 Da
• Isoelectric Point: 8.4956

>T110386 WP_237610688.1 NZ_CP031855:c1990980-1990615 [Actinobacillus pleuropneumoniae]
IDTNVRQWLETIKLGQTNISCITLSEIKTGILLKARKDPIQAERLNHWFTHNVLSVYQAKSFSINNEIALLASEYHIPNK
MDLNDAYIAATAKYHNLVLVTRNLKDFNRCDIRLFNPFEPN

Nucleotide

• Length: 366 bp

>T110386 NZ_CP031855:c1990980-1990615 [Actinobacillus pleuropneumoniae]
ATAGATACCAATGTACGACAATGGTTAGAAACGATTAAACTGGGTCAGACGAATATTAGCTGTATCACGCTTTCCGAAAT
AAAAACGGGGATTTTACTTAAAGCTCGTAAAGATCCTATTCAAGCCGAGCGGTTAAATCATTGGTTTACCCATAATGTAT
TAAGCGTTTATCAAGCTAAATCCTTTTCTATAAATAATGAAATTGCGTTACTGGCTTCTGAATACCACATTCCAAATAAA
ATGGATTTAAACGATGCTTATATTGCCGCAACCGCTAAATATCATAATTTAGTGCTTGTTACTCGTAATTTGAAAGACTT
CAACCGTTGCGATATACGTTTATTTAATCCTTTCGAACCGAATTAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11040.29 Da
• Isoelectric Point: 4.5578

>AT110386 WP_005599447.1 NZ_CP031855:c1991330-1991043 [Actinobacillus pleuropneumoniae]
MPITITSREFNQHASKVLKMAEKEPVFITKWGKIVSVVSNYVDYKQHTTVEPSFEELFASSTDESVSDEFWQDFEQTLTK
IRKSNKSEQIDFGDE

Nucleotide

• Length: 288 bp

>AT110386 NZ_CP031855:c1991330-1991043 [Actinobacillus pleuropneumoniae]
ATGCCAATTACTATTACCTCTCGAGAATTTAATCAACACGCCAGTAAAGTGCTGAAAATGGCAGAAAAAGAACCGGTTTT
TATCACTAAATGGGGAAAAATTGTCAGCGTTGTCTCCAATTATGTTGATTACAAACAGCACACAACGGTTGAGCCTAGCT
TTGAAGAACTATTTGCCTCATCTACGGATGAATCGGTTAGCGATGAGTTTTGGCAAGATTTTGAACAGACATTAACAAAA
ATTCGCAAAAGTAATAAATCCGAACAAATAGATTTTGGAGATGAATAA

Structures

Antitoxin

• AlphaFold DB: A3N3C5