Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1907184..1907812 Replicon chromosome
Accession NZ_CP031855
Organism Actinobacillus pleuropneumoniae strain 7311555

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D1111_RS08830 Protein ID WP_215577974.1
Coordinates 1907414..1907812 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D1111_RS08825 Protein ID WP_039709385.1
Coordinates 1907184..1907414 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1111_RS08815 (D1111_08885) 1905032..1906663 + 1632 WP_237610332.1 hypothetical protein -
D1111_RS08820 1906936..1907109 - 174 Protein_1696 addiction module antidote protein, HigA family -
D1111_RS08825 (D1111_08890) 1907184..1907414 + 231 WP_039709385.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D1111_RS08830 (D1111_08895) 1907414..1907812 + 399 WP_215577974.1 tRNA(fMet)-specific endonuclease VapC Toxin
D1111_RS08835 (D1111_08900) 1907947..1908363 - 417 WP_237610333.1 DUF417 family protein -
D1111_RS08840 (D1111_08905) 1908609..1909259 + 651 WP_237610334.1 DUF2202 domain-containing protein -
D1111_RS08845 (D1111_08910) 1909332..1909991 - 660 WP_005605767.1 hypothetical protein -
D1111_RS08850 (D1111_08915) 1910305..1911627 - 1323 WP_018652450.1 HslU--HslV peptidase ATPase subunit -
D1111_RS08855 (D1111_08920) 1911682..1912203 - 522 WP_005618211.1 ATP-dependent protease subunit HslV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1892503..1909991 17488


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(6-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15091.37 Da        Isoelectric Point: 7.4195

>T110385 WP_215577974.1 NZ_CP031855:1907414-1907812 [Actinobacillus pleuropneumoniae]
MLTYMLDTNIAIYVIKRRPIEVLDKFNLNSTRLCVSSITAAELYYGAEKSQFPERNMAVIEDFLSRLTILDYTHKAATHF
GNIKAHLSKQGKIIGENDIHIAAHARSEGLVLVTNNLREFERVEGLRLDNWV

Download         Length: 399 bp

>T110385 NZ_CP031855:1907414-1907812 [Actinobacillus pleuropneumoniae]
ATGCTAACTTATATGCTTGATACTAACATTGCGATTTATGTGATTAAACGCAGACCTATTGAAGTGCTGGATAAGTTTAA
TTTAAATTCTACTCGTCTTTGTGTAAGTAGTATCACTGCAGCGGAGTTGTATTATGGTGCAGAGAAAAGCCAGTTTCCGG
AACGAAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGCGGCTACTCACTTT
GGCAATATCAAAGCACATTTATCTAAGCAAGGTAAGATCATTGGCGAGAACGATATTCATATTGCCGCACATGCAAGAAG
TGAAGGACTCGTATTAGTGACCAATAACTTGCGTGAATTTGAACGTGTGGAAGGATTGCGATTAGATAATTGGGTATAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8581.65 Da        Isoelectric Point: 4.5203

>AT110385 WP_039709385.1 NZ_CP031855:1907184-1907414 [Actinobacillus pleuropneumoniae]
MEASVFMTNRSQAVRLPAEVRFASDVKKLSVRVVGNERILAPINQSWDSFFLGSATVSDDFMTEREISTQAEREDL

Download         Length: 231 bp

>AT110385 NZ_CP031855:1907184-1907414 [Actinobacillus pleuropneumoniae]
ATGGAAGCATCGGTATTTATGACAAACCGTAGTCAAGCGGTACGATTGCCGGCAGAAGTACGCTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTAGTCGGTAATGAGCGTATTTTGGCTCCGATTAACCAAAGTTGGGATAGCTTCTTTCTGGGGT
CGGCAACGGTAAGCGATGATTTCATGACAGAGCGTGAAATCAGCACTCAAGCCGAACGTGAGGATCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References