Detailed information of TA system TA110384

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1845784..1847441
• Replicon: chromosome
• Accession: NZ_CP031855
• Organism: Actinobacillus pleuropneumoniae strain 7311555

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: D1111_RS08565
• Protein ID: WP_237610314.1
• Coordinates: 1846110..1847441 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A3N2X7
• Locus tag: D1111_RS08560
• Protein ID: WP_005613259.1
• Coordinates: 1845784..1846113 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1111_RS08540 (D1111_08610)	1843114..1843731	+	618	WP_237610310.1	dimethylsulfoxide reductase subunit B	-
D1111_RS08545 (D1111_08615)	1843733..1844566	+	834	WP_237610311.1	dimethyl sulfoxide reductase anchor subunit	-
D1111_RS08550 (D1111_08620)	1844622..1845227	+	606	WP_237610312.1	Tat proofreading chaperone DmsD	-
D1111_RS08555 (D1111_08625)	1845231..1845740	+	510	WP_237610313.1	ferredoxin-type protein NapF	-
D1111_RS08560 (D1111_08630)	1845784..1846113	-	330	WP_005613259.1	helix-turn-helix domain-containing protein	Antitoxin
D1111_RS08565 (D1111_08635)	1846110..1847441	-	1332	WP_237610314.1	HipA domain-containing protein	Toxin
D1111_RS08570 (D1111_08640)	1847773..1849464	-	1692	WP_042655118.1	AIPR family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (164-379)

Antitoxin

• Cro/C1-type helix-turn-helix domain (39-94)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51157.15 Da
• Isoelectric Point: 5.0347

>T110384 WP_237610314.1 NZ_CP031855:c1847441-1846110 [Actinobacillus pleuropneumoniae]
MSDISVKNKKLTLQTYVDNLWRDMAELYFNAQYELESMEYLTDYAVDFFGQANARSISINYPVNVFIDHADKLMTTLADI
IPAGASRRYWLEALDIKHLSISHQNYLLLKNGAISPIGNVRVKEAVPEIQSERYFPLNVVQNRQSDFLEYANQTGAMVGG
ATGAGGEAPKLLLKCQDKQVWIDNLQLGLDCDTAYLVKYPRGNYSELDCDILRAEYHYYHELRALGFSTIDTDLMKLEEG
ERYPSLWLPRFDMKFKDGKWERYAMESVYSMLQKYGGNLDHEQTIRNLLNIISASQFSNDFDNRHFVIEWVKRDLLNIAF
GNSDNHGRNTAFLRDDNRIWLSPIYDFAPMRADPEGIIRTTTWAKNGDNPQEFAGEYRFDKIADGLSDLIEPDILLRELR
MLATQLVDLKSRLMKRGVPKIILDFPAIGFDYLPEKLQRWGLV

Nucleotide

• Length: 1332 bp

>T110384 NZ_CP031855:c1847441-1846110 [Actinobacillus pleuropneumoniae]
ATGAGTGATATATCAGTCAAAAATAAAAAATTAACATTGCAGACCTATGTTGATAATCTATGGCGAGATATGGCGGAGCT
TTATTTCAATGCTCAGTATGAATTAGAGAGCATGGAATATTTAACGGACTATGCCGTCGATTTTTTTGGGCAAGCGAATG
CCAGATCCATATCAATTAATTATCCTGTAAATGTGTTTATTGATCATGCCGATAAGCTGATGACTACACTTGCCGATATT
ATTCCTGCCGGAGCGAGTCGGCGTTATTGGCTGGAAGCTCTTGATATCAAGCACCTATCTATTTCTCATCAAAATTACTT
ATTGCTAAAAAATGGCGCAATATCCCCTATCGGCAATGTCCGAGTTAAAGAGGCTGTGCCAGAAATACAAAGTGAGCGTT
ATTTTCCATTAAATGTGGTACAAAACAGGCAGAGTGATTTTTTAGAATATGCAAATCAGACAGGAGCTATGGTAGGCGGA
GCGACTGGGGCTGGGGGAGAAGCACCAAAGCTATTACTTAAATGCCAAGATAAACAAGTTTGGATTGATAATTTACAATT
AGGTCTAGATTGCGATACGGCTTATTTAGTGAAATATCCTCGTGGGAATTATTCAGAGTTGGACTGTGATATTTTAAGAG
CTGAATATCATTATTATCATGAGCTGCGTGCATTAGGGTTTTCAACTATAGATACTGATCTAATGAAATTAGAAGAGGGG
GAACGTTATCCGTCTTTATGGCTACCTAGATTCGATATGAAGTTCAAAGATGGAAAATGGGAGCGATATGCTATGGAATC
GGTTTATTCTATGTTACAAAAATATGGTGGAAATCTTGATCATGAGCAGACTATTCGCAACTTACTCAATATTATTTCAG
CTTCGCAATTTTCTAATGATTTTGATAACCGGCATTTTGTTATTGAATGGGTAAAGCGAGATTTGTTGAATATTGCTTTT
GGAAATAGTGATAATCATGGCAGAAATACTGCATTTTTACGTGATGATAATCGTATTTGGCTATCCCCTATCTATGATTT
TGCTCCGATGCGGGCAGATCCGGAAGGCATTATCAGAACGACCACTTGGGCTAAAAATGGAGATAACCCTCAAGAGTTCG
CCGGAGAATATCGCTTTGATAAAATAGCTGACGGTTTATCTGACCTTATTGAACCAGATATATTGTTAAGAGAATTAAGA
ATGCTTGCTACCCAATTAGTAGATTTAAAATCTAGACTTATGAAGCGAGGTGTTCCGAAAATTATTTTAGATTTTCCCGC
CATTGGTTTTGATTACTTACCTGAGAAGTTACAACGTTGGGGGCTGGTATGA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 12320.45 Da
• Isoelectric Point: 10.8292

>AT110384 WP_005613259.1 NZ_CP031855:c1846113-1845784 [Actinobacillus pleuropneumoniae]
MTIQHKNASPTRSKVNGIERQLIRETIIVQLLKGEISQGQALRRLRVEALGINQQDYLKLAKVSRQTLSNIENDKGNYSI
ETINQVFKPMGLKLGLMPISKDLMASFLK

Nucleotide

• Length: 330 bp

>AT110384 NZ_CP031855:c1846113-1845784 [Actinobacillus pleuropneumoniae]
ATGACGATTCAACATAAAAATGCCTCACCGACGCGATCTAAAGTGAATGGCATTGAACGACAATTAATCCGTGAAACGAT
TATAGTACAGCTCTTAAAAGGTGAGATTAGTCAAGGACAAGCACTACGTCGATTACGGGTAGAAGCATTAGGAATAAACC
AGCAAGATTATCTGAAATTAGCGAAAGTTTCTCGGCAAACGCTTTCTAATATCGAAAATGATAAAGGAAACTATAGTATA
GAGACAATTAATCAGGTATTTAAACCGATGGGACTAAAGCTAGGTCTTATGCCGATCTCAAAAGACTTGATGGCTTCCTT
TCTTAAATAA

Structures

Antitoxin

• AlphaFold DB: A3N2X7