Detailed information of TA system TA110382

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): toxTA/Tad-couple_hipB
• Location: 1489909..1490554
• Replicon: chromosome
• Accession: NZ_CP031855
• Organism: Actinobacillus pleuropneumoniae strain 7311555

Toxin (Protein)

• Gene name: toxT
• Uniprot ID: B0BQU7
• Locus tag: D1111_RS06780
• Protein ID: WP_005619674.1
• Coordinates: 1490183..1490554 (-)
• Length: 124 a.a.

Antitoxin (Protein)

• Gene name: toxA
• Uniprot ID: -
• Locus tag: D1111_RS06775
• Protein ID: WP_005598477.1
• Coordinates: 1489909..1490202 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1111_RS06745 (D1111_06805)	1485241..1485924	-	684	WP_005605188.1	arginine ABC transporter permease ArtM	-
D1111_RS06750 (D1111_06810)	1485924..1486595	-	672	WP_005612835.1	arginine ABC transporter permease ArtQ	-
D1111_RS06755 (D1111_06815)	1486601..1487320	-	720	WP_005619670.1	transporter substrate-binding domain-containing protein	-
D1111_RS06760 (D1111_06820)	1487340..1488074	-	735	WP_005598473.1	arginine ABC transporter ATP-binding protein ArtP	-
D1111_RS06765 (D1111_06825)	1488299..1488796	-	498	WP_237610230.1	YbhB/YbcL family Raf kinase inhibitor-like protein	-
D1111_RS06770 (D1111_06830)	1488869..1489831	+	963	WP_237610231.1	calcium/sodium antiporter	-
D1111_RS06775 (D1111_06835)	1489909..1490202	-	294	WP_005598477.1	helix-turn-helix domain-containing protein	Antitoxin
D1111_RS06780 (D1111_06840)	1490183..1490554	-	372	WP_005619674.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1111_RS06785 (D1111_06845)	1490748..1492499	+	1752	WP_237610232.1	protein-disulfide reductase DsbD	-
D1111_RS06790 (D1111_06850)	1492557..1493126	+	570	WP_237610233.1	elongation factor P hydroxylase	-
D1111_RS06795 (D1111_06855)	1493170..1494024	-	855	WP_005615766.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (32-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-85)

Sequences

Toxin

Protein

• Length: 124 a.a.
• Molecular weight: 15066.57 Da
• Isoelectric Point: 10.4054

>T110382 WP_005619674.1 NZ_CP031855:c1490554-1490183 [Actinobacillus pleuropneumoniae]
MYEIVFYRDKRGREPVKEFLLRLLKERQEGSRERLHKISHHLSILHLHGTRAGENYIKHLEDRIWQLRPVGDCLLFASII
RGKFVLLHYFAKQNYRIPKREIERAKVRLADLQERIKDEPYWF

Nucleotide

• Length: 372 bp

>T110382 NZ_CP031855:c1490554-1490183 [Actinobacillus pleuropneumoniae]
ATGTATGAAATAGTCTTTTATCGAGATAAGCGGGGGAGAGAACCCGTAAAAGAATTTCTGTTAAGGCTACTAAAAGAACG
GCAGGAAGGCAGTCGAGAACGATTACACAAAATCAGCCATCATTTGAGTATTTTACATTTGCACGGTACTCGAGCCGGTG
AGAATTATATTAAGCATTTGGAAGATCGTATTTGGCAGTTACGTCCGGTGGGCGATTGCCTGTTATTTGCAAGTATTATT
CGGGGAAAATTTGTGTTGTTGCATTATTTTGCCAAACAGAATTATCGAATTCCGAAACGAGAAATAGAACGTGCAAAAGT
TCGGTTGGCGGATTTACAGGAGAGAATAAAAGATGAGCCCTATTGGTTCTAG

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10935.81 Da
• Isoelectric Point: 10.3120

>AT110382 WP_005598477.1 NZ_CP031855:c1490202-1489909 [Actinobacillus pleuropneumoniae]
MSPIGSSWTSFEQEIFDESEIAETQFRIRLILEIIETRQQLGISQRKLEKLSGVKQSMIARVEKGSVNPSLATVLKLLVP
LGKTLQIVPLDKNKTVR

Nucleotide

• Length: 294 bp

>AT110382 NZ_CP031855:c1490202-1489909 [Actinobacillus pleuropneumoniae]
ATGAGCCCTATTGGTTCTAGTTGGACATCGTTTGAACAAGAAATTTTTGACGAGTCGGAAATAGCGGAAACTCAGTTTCG
CATACGACTTATTTTAGAAATCATTGAAACCCGTCAGCAGCTCGGTATTTCTCAACGAAAATTGGAGAAATTAAGCGGTG
TAAAACAATCTATGATTGCTCGGGTAGAAAAAGGCTCGGTTAATCCGTCGTTGGCGACGGTATTAAAGTTGCTTGTGCCG
TTGGGGAAAACTTTACAAATCGTACCGTTAGATAAAAACAAAACGGTACGTTAA

Structures

Toxin

• AlphaFold DB: A3N206