Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/ElaA-DUF1778 |
| Location | 116732..117471 | Replicon | plasmid pKP121-2 |
| Accession | NZ_CP031851 | ||
| Organism | Klebsiella pneumoniae strain 121 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | - |
| Locus tag | D1Y71_RS27935 | Protein ID | WP_021312536.1 |
| Coordinates | 116732..117217 (-) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | L7SZ29 |
| Locus tag | D1Y71_RS27940 | Protein ID | WP_003026799.1 |
| Coordinates | 117205..117471 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| D1Y71_RS27885 | 112113..112526 | - | 414 | WP_136398523.1 | helix-turn-helix domain-containing protein | - |
| D1Y71_RS27890 | 112527..112805 | - | 279 | WP_136398524.1 | helix-turn-helix domain-containing protein | - |
| D1Y71_RS27895 | 112795..113115 | - | 321 | Protein_110 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| D1Y71_RS27900 | 113195..113419 | - | 225 | WP_004152719.1 | hypothetical protein | - |
| D1Y71_RS27905 | 113430..113642 | - | 213 | WP_013023815.1 | hypothetical protein | - |
| D1Y71_RS27910 | 113703..114059 | - | 357 | WP_013023814.1 | hypothetical protein | - |
| D1Y71_RS27915 | 114902..115219 | - | 318 | WP_032747192.1 | hypothetical protein | - |
| D1Y71_RS27920 | 115234..115584 | - | 351 | WP_042938321.1 | hypothetical protein | - |
| D1Y71_RS27925 | 115581..115850 | - | 270 | WP_038807148.1 | hypothetical protein | - |
| D1Y71_RS27930 | 116228..116389 | - | 162 | WP_004118124.1 | type I toxin-antitoxin system Hok family toxin | - |
| D1Y71_RS27935 | 116732..117217 | - | 486 | WP_021312536.1 | GNAT family N-acetyltransferase | Toxin |
| D1Y71_RS27940 | 117205..117471 | - | 267 | WP_003026799.1 | DUF1778 domain-containing protein | Antitoxin |
| D1Y71_RS27945 | 117604..118032 | - | 429 | WP_004901287.1 | GFA family protein | - |
| D1Y71_RS27955 | 119802..120176 | - | 375 | WP_001568060.1 | hypothetical protein | - |
| D1Y71_RS27960 | 120232..120558 | - | 327 | WP_001568059.1 | hypothetical protein | - |
| D1Y71_RS27965 | 120555..121283 | - | 729 | WP_001568058.1 | plasmid SOS inhibition protein A | - |
| D1Y71_RS27970 | 121280..121711 | - | 432 | WP_057992126.1 | conjugation system SOS inhibitor PsiB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..134208 | 134208 | |
| - | flank | IS/Tn | - | - | 118233..118865 | 632 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17608.39 Da Isoelectric Point: 10.3370
>T110368 WP_021312536.1 NZ_CP031851:c117217-116732 [Klebsiella pneumoniae]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q
Download Length: 486 bp
>T110368 NZ_CP031851:c117217-116732 [Klebsiella pneumoniae]
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA
GTGGGACGTATAACCGCGCCCGAGCCGTTATCCAGCGCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGAAGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCGCGGAAAAGGGCTTGGCGCTGATTT
ACTTCATGATGCAGTACTTCGTTGCTATCGGGTTGCCGAGAATATAGGTGTACGTGCAATCATGGTTCATGCGCTCACAG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCCGCGGACACTGTTCCTCAGACTCCCT
CAGTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10147.59 Da Isoelectric Point: 4.5256
>AT110368 WP_003026799.1 NZ_CP031851:c117471-117205 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV
Download Length: 267 bp
>AT110368 NZ_CP031851:c117471-117205 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCCGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|