Detailed information of TA system TA110364

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4618601..4619117
• Replicon: chromosome
• Accession: NZ_CP031849
• Organism: Klebsiella pneumoniae strain 121

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D1Y71_RS23185
• Protein ID: WP_021469513.1
• Coordinates: 4618601..4618885 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: D1Y71_RS23190
• Protein ID: WP_002886901.1
• Coordinates: 4618875..4619117 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D1Y71_RS23165	4614077..4614385	-	309	WP_004178377.1	PTS sugar transporter subunit IIB	-
D1Y71_RS29650	4614470..4614643	+	174	WP_032409292.1	hypothetical protein	-
D1Y71_RS23170	4614646..4615389	+	744	WP_085898715.1	MurR/RpiR family transcriptional regulator	-
D1Y71_RS23175	4615746..4617884	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
D1Y71_RS23180	4618133..4618597	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
D1Y71_RS23185	4618601..4618885	-	285	WP_021469513.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D1Y71_RS23190	4618875..4619117	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
D1Y71_RS23195	4619195..4621105	-	1911	WP_032103421.1	BglG family transcription antiterminator	-
D1Y71_RS23200	4621128..4622282	-	1155	WP_032103419.1	lactonase family protein	-
D1Y71_RS23205	4622349..4623089	-	741	WP_002886899.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11083.95 Da
• Isoelectric Point: 10.4962

>T110364 WP_021469513.1 NZ_CP031849:c4618885-4618601 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T110364 NZ_CP031849:c4618885-4618601 [Klebsiella pneumoniae]
ATGACCTATGAACTGGCGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCTGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT110364 WP_002886901.1 NZ_CP031849:c4619117-4618875 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT110364 NZ_CP031849:c4619117-4618875 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCGGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0