Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3899341..3899960 Replicon chromosome
Accession NZ_CP031849
Organism Klebsiella pneumoniae strain 121

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag D1Y71_RS19645 Protein ID WP_002892050.1
Coordinates 3899742..3899960 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag D1Y71_RS19640 Protein ID WP_002892066.1
Coordinates 3899341..3899715 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D1Y71_RS19630 3894493..3895686 + 1194 WP_032103325.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
D1Y71_RS19635 3895709..3898855 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
D1Y71_RS19640 3899341..3899715 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
D1Y71_RS19645 3899742..3899960 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
D1Y71_RS19650 3900119..3900685 + 567 WP_136398401.1 maltose O-acetyltransferase -
D1Y71_RS29525 3900657..3900797 - 141 WP_004147370.1 hypothetical protein -
D1Y71_RS19655 3900818..3901288 + 471 WP_002892026.1 YlaC family protein -
D1Y71_RS19660 3901263..3902714 - 1452 WP_136398402.1 PLP-dependent aminotransferase family protein -
D1Y71_RS19665 3902815..3903513 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
D1Y71_RS19670 3903510..3903650 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
D1Y71_RS19675 3903650..3903913 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T110362 WP_002892050.1 NZ_CP031849:3899742-3899960 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T110362 NZ_CP031849:3899742-3899960 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT110362 WP_002892066.1 NZ_CP031849:3899341-3899715 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT110362 NZ_CP031849:3899341-3899715 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References