Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1186243..1187796 Replicon chromosome
Accession NZ_CP031848
Organism Marinobacter sp. Arc7-DN-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag D0851_RS05505 Protein ID WP_117617723.1
Coordinates 1186495..1187796 (+) Length 434 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag D0851_RS05500 Protein ID WP_117617722.1
Coordinates 1186243..1186491 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0851_RS05465 1182078..1182836 - 759 WP_117617715.1 lipopolysaccharide biosynthesis protein -
D0851_RS05470 1183114..1183545 - 432 WP_117617716.1 putative toxin-antitoxin system toxin component, PIN family -
D0851_RS05475 1183561..1183833 - 273 WP_117617717.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
D0851_RS05480 1183990..1184469 - 480 WP_117617718.1 transcription/translation regulatory transformer protein RfaH -
D0851_RS05485 1184556..1185329 - 774 WP_117617719.1 3'(2'),5'-bisphosphate nucleotidase CysQ -
D0851_RS05490 1185372..1185737 - 366 WP_117617720.1 type II toxin-antitoxin system VapC family toxin -
D0851_RS05495 1185727..1185951 - 225 WP_117617721.1 hypothetical protein -
D0851_RS05500 1186243..1186491 + 249 WP_117617722.1 helix-turn-helix domain-containing protein Antitoxin
D0851_RS05505 1186495..1187796 + 1302 WP_117617723.1 type II toxin-antitoxin system HipA family toxin Toxin
D0851_RS05510 1188235..1189596 + 1362 WP_117617724.1 MBL fold metallo-hydrolase -
D0851_RS05515 1189653..1189979 - 327 WP_117617725.1 nucleotidyltransferase domain-containing protein -
D0851_RS05520 1189966..1190394 - 429 WP_117617726.1 nucleotidyltransferase substrate binding protein -
D0851_RS05525 1190709..1191152 - 444 WP_117617727.1 pilin -
D0851_RS05530 1191470..1191898 - 429 WP_117620296.1 hypothetical protein -
D0851_RS05535 1192074..1192373 - 300 WP_205422274.1 HigA family addiction module antidote protein -
D0851_RS05540 1192386..1192664 - 279 WP_117620298.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 434 a.a.        Molecular weight: 47967.93 Da        Isoelectric Point: 8.1507

>T110339 WP_117617723.1 NZ_CP031848:1186495-1187796 [Marinobacter sp. Arc7-DN-1]
MPDLTVALNGIQVGRLTLERSGAMAFQYLPDWLSRPGARAISLSLPLAPAPYRGAKVYNFFDNLLPDSEAIRSRMQARFG
APTRHPFDLLSSVGRDCIGAVQLYPETSEIPDVRSVTASPLDASAVENILGNYQDAPFGVAGDHDFRISLAGAQEKTALL
WHRNQWCLPAGSTPTSHIFKLPIGFLNHSNMDLRESSENEWLCLQILKAFGLPVANAQLARFGKQKVLIVERFDRRWSSD
NTWLMRLPQEDFCQSLGVAPAAKYESDGGPGIQDAMTLLLGSQEPTKDRELFFRAQILFWLMAAIDGHAKNFSLFIEPGS
AYRMTPLYDVISAYPLIAQGSMAAEKAKMAMALKGRNRHYHWARIQARHFVSTAQQVGFSAEKAKSLMKDVAEQTRPVIQ
SVEARLPADFPPRVSEPILNGVARQSEVLSAQL

Download         Length: 1302 bp

>T110339 NZ_CP031848:1186495-1187796 [Marinobacter sp. Arc7-DN-1]
ATGCCTGATTTGACCGTTGCCCTGAATGGCATCCAGGTAGGCAGACTGACCCTTGAGCGGTCTGGCGCCATGGCGTTTCA
GTACCTTCCCGATTGGTTAAGCCGGCCGGGTGCCAGGGCTATCTCACTCTCGCTGCCCCTTGCACCCGCACCTTACCGTG
GCGCAAAGGTTTATAACTTCTTCGATAACCTGCTGCCAGATTCCGAAGCAATCCGTTCGCGCATGCAGGCCCGGTTCGGG
GCGCCAACACGGCATCCTTTTGACCTGCTCTCGAGCGTTGGCCGGGACTGTATTGGTGCAGTTCAACTCTACCCTGAGAC
GTCTGAAATACCCGATGTCCGCTCCGTGACAGCTTCACCCCTGGATGCCTCAGCGGTGGAGAATATTCTCGGCAACTACC
AGGATGCGCCCTTCGGAGTAGCGGGGGACCATGATTTCCGGATATCCCTTGCCGGTGCGCAAGAAAAAACTGCCTTGCTT
TGGCACCGGAACCAGTGGTGTCTGCCTGCTGGCAGTACGCCCACCAGCCATATCTTTAAGCTCCCGATTGGATTTTTGAA
TCACAGCAATATGGACTTACGGGAAAGCAGCGAAAACGAATGGCTCTGCTTGCAGATTCTGAAGGCGTTTGGGCTGCCGG
TTGCCAACGCACAGCTGGCTCGGTTCGGGAAGCAGAAAGTGCTGATTGTTGAACGATTCGATCGGCGTTGGTCGAGCGAT
AACACCTGGCTAATGCGCCTGCCTCAGGAGGATTTTTGCCAGTCTCTTGGTGTGGCGCCGGCCGCCAAATACGAAAGTGA
CGGTGGCCCCGGCATTCAGGACGCCATGACATTGTTGCTCGGATCTCAGGAGCCCACCAAGGATCGGGAGCTGTTTTTCA
GGGCACAGATTCTCTTCTGGCTAATGGCTGCCATTGACGGCCACGCAAAAAACTTCAGCCTGTTTATAGAGCCAGGCTCC
GCCTATCGGATGACACCATTGTACGATGTTATTTCGGCCTATCCGCTTATCGCTCAGGGAAGCATGGCCGCAGAGAAGGC
AAAAATGGCGATGGCCCTGAAAGGCCGCAACCGCCATTACCATTGGGCTCGCATCCAGGCCCGGCATTTTGTGAGCACCG
CCCAACAGGTCGGTTTCTCTGCCGAGAAAGCAAAAAGCCTGATGAAAGACGTAGCCGAGCAAACCAGACCGGTTATTCAG
TCTGTAGAGGCACGTCTTCCGGCGGACTTCCCTCCACGGGTCAGCGAACCGATTCTGAATGGCGTTGCGAGGCAATCCGA
GGTGTTGTCCGCTCAGCTCTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9492.78 Da        Isoelectric Point: 9.9470

>AT110339 WP_117617722.1 NZ_CP031848:1186243-1186491 [Marinobacter sp. Arc7-DN-1]
MKITSPDALAQEIKNARKRRKLTQQVVSDQIGVKQATISSFENHPERSRVETLFKLLSALDLELRVAKRGDTEQEAKWDQ
EW

Download         Length: 249 bp

>AT110339 NZ_CP031848:1186243-1186491 [Marinobacter sp. Arc7-DN-1]
ATGAAAATCACCTCACCTGATGCGCTTGCCCAGGAAATAAAGAATGCCCGTAAGCGCCGGAAGCTCACCCAGCAGGTTGT
TTCAGATCAGATTGGCGTGAAACAGGCCACCATATCCAGTTTTGAGAACCATCCGGAGCGAAGCCGGGTGGAAACACTGT
TCAAGCTGCTGTCCGCTCTGGATCTTGAGCTGCGTGTGGCCAAGCGCGGCGACACGGAACAGGAAGCGAAATGGGATCAG
GAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References