Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 758919..759571 Replicon chromosome
Accession NZ_CP031848
Organism Marinobacter sp. Arc7-DN-1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag D0851_RS03535 Protein ID WP_205422313.1
Coordinates 759182..759571 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag D0851_RS03530 Protein ID WP_117617387.1
Coordinates 758919..759161 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
D0851_RS03500 754702..756003 - 1302 WP_162893684.1 TolC family protein -
D0851_RS20150 756142..756534 - 393 WP_162893685.1 hypothetical protein -
D0851_RS03510 757043..757345 + 303 WP_117617383.1 type II toxin-antitoxin system HigB family toxin -
D0851_RS03515 757363..757731 + 369 WP_117617384.1 transcriptional regulator -
D0851_RS03520 758087..758335 + 249 WP_117617385.1 type II toxin-antitoxin system ParD family antitoxin -
D0851_RS03525 758335..758634 + 300 WP_117617386.1 type II toxin-antitoxin system RelE/ParE family toxin -
D0851_RS03530 758919..759161 + 243 WP_117617387.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
D0851_RS03535 759182..759571 + 390 WP_205422313.1 PIN domain-containing protein Toxin
D0851_RS03540 759739..761316 - 1578 WP_117617389.1 glutamine-hydrolyzing GMP synthase -
D0851_RS03545 761380..762843 - 1464 WP_117617390.1 IMP dehydrogenase -
D0851_RS03550 763036..764424 + 1389 WP_117617391.1 exodeoxyribonuclease VII large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin

SpoVT-AbrB domain

(11-57)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 13919.94 Da        Isoelectric Point: 5.5434

>T110337 WP_205422313.1 NZ_CP031848:759182-759571 [Marinobacter sp. Arc7-DN-1]
MDTNILSDLVRNPQGVVAAQITKAGEDTVCTSIIVAAELRYGAITSNSAKLAERIDMILSALEILPLETPADHQYASLRH
HLTRQGTPIGPNDLLIAAHALANDLTVITANVREFSRVPGLKVENWLQA

Download         Length: 390 bp

>T110337 NZ_CP031848:759182-759571 [Marinobacter sp. Arc7-DN-1]
CTGGATACCAACATCCTGTCCGATCTTGTCCGCAATCCGCAAGGCGTGGTAGCAGCACAGATCACCAAGGCAGGCGAGGA
TACTGTCTGCACCAGCATCATTGTAGCCGCGGAACTCCGCTATGGCGCAATCACGTCAAACTCTGCAAAACTTGCAGAGC
GCATTGACATGATCCTCTCGGCACTGGAAATCCTGCCACTGGAAACACCCGCCGACCACCAGTACGCATCATTACGCCAT
CACCTCACACGTCAGGGAACACCCATTGGGCCAAATGATCTGCTGATTGCTGCACATGCACTCGCAAATGACCTTACAGT
TATAACCGCCAATGTCAGGGAATTCTCCCGGGTGCCAGGGCTGAAAGTGGAGAACTGGCTACAGGCATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9197.48 Da        Isoelectric Point: 4.5355

>AT110337 WP_117617387.1 NZ_CP031848:758919-759161 [Marinobacter sp. Arc7-DN-1]
MSTSERHVRLFRNGRNQALRIPREFELEGEEALIHKEGDRLIVEPIRKGRLLALLASLDPLTEPFPDIDDDLPPLDDVQL

Download         Length: 243 bp

>AT110337 NZ_CP031848:758919-759161 [Marinobacter sp. Arc7-DN-1]
ATGTCAACTTCTGAACGCCATGTACGCCTCTTTCGCAACGGGCGCAACCAGGCCCTACGCATCCCTCGCGAGTTCGAGTT
GGAGGGTGAGGAAGCACTCATCCACAAGGAGGGTGACCGGCTGATTGTGGAGCCGATCCGTAAAGGCAGGCTGCTGGCGC
TGCTAGCCTCTCTGGATCCCTTGACTGAACCCTTCCCCGATATCGATGATGACCTGCCTCCATTGGATGACGTGCAGCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References