Detailed information of TA system TA110335

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE(toxin)
• Location: 697836..698470
• Replicon: chromosome
• Accession: NZ_CP031848
• Organism: Marinobacter sp. Arc7-DN-1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: D0851_RS03250
• Protein ID: WP_117617336.1
• Coordinates: 698219..698470 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: D0851_RS03245
• Protein ID: WP_117617335.1
• Coordinates: 697836..698216 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
D0851_RS03225	693653..695275	+	1623	WP_117617332.1	FAD-binding oxidoreductase	-
D0851_RS03230	695393..696205	+	813	WP_117617333.1	PEP-CTERM/exosortase system-associated acyltransferase	-
D0851_RS03235	696282..697136	-	855	WP_117617334.1	THxN family PEP-CTERM protein	-
D0851_RS03245	697836..698216	-	381	WP_117617335.1	helix-turn-helix domain-containing protein	Antitoxin
D0851_RS03250	698219..698470	-	252	WP_117617336.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
D0851_RS03255	698674..699843	-	1170	WP_117617337.1	2-methylaconitate cis-trans isomerase PrpF	-
D0851_RS03260	700018..702615	-	2598	WP_117620261.1	Fe/S-dependent 2-methylisocitrate dehydratase AcnD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-80)

Antitoxin

• Cro/C1-type helix-turn-helix domain (69-123)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9470.19 Da
• Isoelectric Point: 10.3701

>T110335 WP_117617336.1 NZ_CP031848:c698470-698219 [Marinobacter sp. Arc7-DN-1]
MYSLKYKKSALKALKKAPRPVAERIMSELEAIALDPDNYRGDWKPMKGKPYWRLRQGGYRAICSFDNGELILLVLKVGAR
GDI

Nucleotide

• Length: 252 bp

>T110335 NZ_CP031848:c698470-698219 [Marinobacter sp. Arc7-DN-1]
ATGTACTCACTGAAATACAAAAAATCCGCACTGAAAGCACTGAAGAAAGCCCCCAGGCCAGTAGCAGAAAGGATAATGTC
CGAACTCGAAGCGATTGCGCTGGATCCAGACAACTACCGTGGCGACTGGAAGCCGATGAAAGGAAAGCCTTATTGGCGCC
TTCGCCAGGGTGGATACAGGGCGATTTGCAGTTTTGATAATGGTGAGCTGATTTTACTGGTATTGAAAGTCGGCGCCAGA
GGAGATATTTAA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13789.57 Da
• Isoelectric Point: 4.3748

>AT110335 WP_117617335.1 NZ_CP031848:c698216-697836 [Marinobacter sp. Arc7-DN-1]
MSVQIIEKSGKPEYAVIPYAEYQELLEMAQDARDIQDADVAMAELSAGEDESIPAAIAKRLMSGDEHPLKIWREYRGYTQ
ESLGTEAGIGKSYVSQIEAGTKTGSTKVLRAIAKALQVEIDDLLGR

Nucleotide

• Length: 381 bp

>AT110335 NZ_CP031848:c698216-697836 [Marinobacter sp. Arc7-DN-1]
ATGAGCGTGCAGATTATTGAAAAATCGGGAAAACCCGAATACGCAGTCATTCCCTATGCCGAGTATCAAGAGTTGCTTGA
GATGGCACAGGATGCGCGTGATATTCAGGATGCCGATGTTGCGATGGCTGAACTTTCCGCCGGAGAAGATGAAAGCATTC
CTGCGGCTATCGCTAAGCGCCTCATGTCTGGAGATGAACACCCGCTGAAGATTTGGAGGGAATATCGCGGCTATACTCAG
GAATCACTGGGCACAGAAGCCGGTATTGGCAAATCGTATGTGTCACAAATTGAGGCTGGCACCAAAACGGGTTCAACAAA
AGTTCTCAGAGCGATTGCGAAAGCTTTGCAGGTTGAAATAGACGATCTGTTGGGCCGATAG